Allium hirtifolium Boiss: Radical scavenging property and the lowering effects on blood fibrinogen and factor VII

Asgari, Sedigheh. and Rafieian-Kopaei, Mahmoud. and Pourgheysari, Batoul. and Ansari Samani, Roya. and Deris, Fatemeh. and Shahinfard, Najmeh. and Hojjati, Mohammad reza. and Salimi, Mahmoud. (2012) Allium hirtifolium Boiss: Radical scavenging property and the lowering effects on blood fibrinogen and factor VII. LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION, 9 (3). pp. 1793-1798.

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Abstract

Enhancement of blood fibrinogen or factor VII increases cardiovascular diseases. Allium hirtifolium Boiss (Mosir) has been shown to have cardioprotective effect. This study, therefore, aimed to evaluate the effects of Allium hirtifolium Boiss on factor VII and fibrinogen blood levels. Its radical scavenging property was also measured. Twenty four NewZealand male rabbits were randomly designated into 3 groups of 8 and were fed for 60 days with normal diet, hypercholestrol (1%) diet or hypercholestrol (1%) diet+Mosir. At the beginning and 60 days after the start of the study, the blood fibrinogen and factor 7 were measured and compared in different groups. The Mosir radical scavenging property was measured using the beta-carotene linoleate method. The blood fibrinogen and factor 7 were higher in hypercholesterolemic group (26.7 +/- 329.22 and 17.1 +/- 277.7mg/dl) compared to normal diet group (13.7 +/- 287.25 and 18.2 +/- 230.0 mg/dl, respectively) (P<0.05), at the end of the experiment. The amount of blood fibrinogen and factor 7 were decreased in hypercholesterol+Mosir group (23.9 +/- 180.00 and 53.3 +/- 237.0 mg/dl) compared to hypercholesterol diet group (P<0.05). radical scavenging activity of Mosir extract was 52.1 +/- 3.3%. Mosir may have beneficial effect on heart by decreasing blood fibrinogen and factor 7 as cardiovascular risk factors. These effects of Mosir should be considered carefully in patients with hemostatic disorders. Asgari. S, Rafieian-kopaei. M, Pourgheysari. B, Ansari-Samani. R, Deris F, Shahinfard. N, Hojjati. MR and Salimi. M. Allium hirtifolium Boiss: Radical scavenging property and the lowering effects on blood fibrinogen and factor VII. Life Sci J 2012;9(3):1793-1798] (ISSN:1097-8135). http://www.lifesciencesite.com. 259

Item Type: Article
Uncontrolled Keywords: Rabbit; Fibrinogen; Factor 7; Hypercholesterolemia; Allium hirtifolium Boiss
Subjects: WH Hemic and Lymphatic System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 14 Aug 2017 08:55
Last Modified: 17 Apr 2018 07:08
URI: http://eprints.skums.ac.ir/id/eprint/2915

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