Postprandial hypolipidemic and hypoglycemic effects of Allium hertifolium and Sesamum indicum on hypercholesterolemic rabbits

Asgari, Sedigheh. and Setorki, Mahbubeh. and Rafieian-Kopaei, Mahmoud. and Heidarian, Esfandiar. and Shahin Fard, Najmeh. and Ansari Samani, Roya. and Foroozandeh, Zahra. (2012) Postprandial hypolipidemic and hypoglycemic effects of Allium hertifolium and Sesamum indicum on hypercholesterolemic rabbits. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 6 (15). pp. 1131-1135.

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Abstract

Oxidative stress associated with postprandial hyperlipidemia contributes to endothelial dysfunction, which shifts hemostasis to a more thrombogenic state. The present study was undertaken to evaluate the effect of Allium hertifolium and Sesamum indicum on postprandial lipemic, glycemic profile and endothelial markers in hypercholesterolemic rabbits. A total of 32 male rabbits were randomized into 4 groups: Group 1: Control group (normal group); Group 2: Hypercholesterolemic diet (1% cholesterol); Group 3: 1% cholesterol administered with A. hertifolium extract (2% of diet); Group 4: 1% cholesterol administered with S. indicum powder (10% of diet). The serum was analyzed for lipid profile (total cholesterol (TC); triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), ApoB), glucose, nitrite, nitrate, serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) levels and plasma was analyzed for fibrinogen and factor VII. These factors were measured in blood samples following 15 h of fasting and 3 h after feeding. The results showed A. hertifolium and S. indicum to be effective in reducing SGPT, fibrinogen, total cholesterol (TC) and LDL-C values in comparison with hypercholesterolemic diet group. Consumption of A. hertifolium and S. indicum did not significantly change factor VII, ApoB and nitrite levels in comparison with hypercholesterolemic diet group. Intake of S. indicum significantly decreased serum SGOT, nitrate, glucose and TG compared to hypercholesterolemic diet group. A. hertifolium and S. indicum with a high content of phenolic compounds change the postprandial profile lipids, endothelial markers and trombogenic factors and might be beneficial in patients with cardiovascular diseases.

Item Type: Article
Uncontrolled Keywords: Allium hertifolium; Sesamum indicum; postprandial; serum glutamic pyruvic transaminase (SGPT)
Subjects: QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 14 Aug 2017 05:41
Last Modified: 03 Feb 2018 05:13
URI: http://eprints.skums.ac.ir/id/eprint/2883

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