Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients.

Rouhi, H. and Ganji, F. (2013) Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients. Journal of nephropathology, 2 (1). pp. 61-6. ISSN 2251-8363


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BACKGROUND About 30-40% of diabetic patients who developed nephropathy have lipoprotein disorders, especially lipoprotein a [Lp(a)], which is related to atherosclerosis. OBJECTIVES The aim of this study was to investigate the effect of N-acetyl cysteine (NAC) on the serum levels of Lp(a) and amount of proteinuria in a group of type 2 diabetic patients with diabetic nephropathy. PATIENTS AND METHODS A total of 40, type 2 diabetic (T2D) patients, patients with proteinuria, were randomly divided into two groups. The experimental group was treated by NAC (1200 mg/day) for two months in conjunction with conventional treatment for diabetes and hypertension. Control group received routine medications. RESULTS No significant change was identified in serum Lp(a) during treatment with NAC (P >0.05). However, NAC decreased the amount of proteinuria, serum triglyceride (TG) level and systolic blood pressure in experimental group compared to the control group (P <0.05). CONCLUSIONS These findings suggest that treatment with NAC has no significant effect on the serum level of Lp (a). However, it has beneficial effects on the reduction of proteinuria, serum TG level and systolic blood pressure in T2D patients with nephropathy. Further prospective studies are needed to determine its full role.

Item Type: Article
Uncontrolled Keywords: Diabetic nephropathy Lipoprotein(a) N-acetyl cysteine (NAC)
Subjects: WG Cardiovascular System
WJ Urogenital System
Divisions: Faculty of Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: Users 1 not found.
Date Deposited: 13 Aug 2017 04:33
Last Modified: 13 Aug 2017 04:33
URI: http://eprints.skums.ac.ir/id/eprint/2783

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