Effect of turnip on glucose and lipid profiles of alloxan-induced diabetic rats

Akbari, Fatemeh. and Ansari Samani, Roya. and Karimi, Ali. and Mortazaei, Seifollah. and Shahinfard, Najmeh. and Rafieian-Kopaei, Mahmoud. (2013) Effect of turnip on glucose and lipid profiles of alloxan-induced diabetic rats. Iranian Journal of Endocrinology and Metabolism, 14 (5).

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Abstract

Introduction: In traditional medicine turnip (Brassica napus), is used to reduce blood glucose. Furthermore, Turnip also has antioxidant effects and many plants with antioxidant activities are known to have antidiabetic properties. Therefore in this study, the antihyperglycemic effect of boiled turnip extract and metabolic changes on triglycerides, cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) in diabetic rats were investigated. Materials and Methods: In this experimental study, 40 male Wistar rats, weighing 200 to 250g were divided in to 4 groups: control, diabetic control, diabetic group receiving cooked Turnip and diabetic group receiving Glibenclamide. Diabetes was induced by injection of 120 mg/kg alloxan monohydrate on 3 consecutive days. Rats in the third group received 16ml/kg turnip extract daily for 4 weeks after which the animals were anesthetized and blood samples were taken to measure the factors mentoned. Data were analyzed by Analysis of Variance test using SPSS software. Results: Boiled turnip extract significantly reduced serum glucose, triglycerides, cholesterol and LDL, and increase HDL, in diabetic rats compared to the control diabetic group (p<0.05). Conclusion: This study demonstrated that boiled turnip extract can reduce blood glucose and lipid levels in diabetic rats and may be used as complementary or alternative treatment for diabetic patients.

Item Type: Article
Additional Information: cited By 14
Uncontrolled Keywords: alloxan; cholesterol; glibenclamide; glucose; high density lipoprotein; lipid; low density lipoprotein; plant extract; triacylglycerol; turnip extract; unclassified drug, alloxan-induced diabetes mellitus; animal experiment; animal model; antidiabetic activity; article; cholesterol blood level; controlled study; glucose blood level; male; metabolic regulation; nonhuman; rat; turnip
Subjects: WD Nutrition Disease and metabolic diseases
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 09 Aug 2017 05:31
Last Modified: 03 Feb 2018 07:46
URI: http://eprints.skums.ac.ir/id/eprint/2735

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