Effects of portulaca oleracea L (purslane) on psychological symptoms of chronic schizophrenic patients in Sina hospital

Parvin, Neda. and Farzane Dehkordi, Shokoh. and Goodarzi, Iraj. and Nikfarjam, Masoud. and Rafieian-Kopaei, Mahmoud. and Heidarian, Esfandiar. and Rafiee Vardanjani, Leila. (2013) Effects of portulaca oleracea L (purslane) on psychological symptoms of chronic schizophrenic patients in Sina hospital. Journal of Mazandaran University of Medical Sciences, 23 (97). pp. 2-10.

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Abstract

Background and purpose: Despite the availability of typical and atypical antipsychotic drugs, a large number of patients with schizophrenia do not show a good response to monotherapy with these drugs. This study was done to evaluate the effect of purslane on psychological symptoms of schizophrenic patients. Materials and methods: This randomized clinical trial was carried out in 60 chronic schizophrenic patients treated with risperidone in Sina hospital Joneghan, Iran during 2011-2012. The patients were randomly divided into intervention and control groups. The control group received risperidone 6mg/day and Biperiden 4mg/day for eight weeks. The Patients in the interventional group received 1gr extract of purslane daily with the same regimen for eight weeks. The scales for assessment of positive symptoms (SAPS), assessment of negative symptoms (SANS) and CRP level were recorded prior to and 8th week after the study. The data was then analyzed using SPSS V. 16. Results: At the end of study, the mean score of positive symptoms were 47.93 ± 18.56 and 57.1 ± 14.83 in intervention and control groups, respectively (P<0.05), and the mean score of negative symptoms were 40.83 ± 11.03 and 46.13 ± 9.34, respectively (P<0.05). The CRP levels of patients in intervention and control groups were 0.53 ± 0.55 and 1.72 ± 0.73, respectively (P<0.05). Conclusion: According to findings using purslane as an adjunct to respridone can improve psychological condition of chronic schizophrenic patients and decrease their CRP levels.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: biperiden; C reactive protein; Portulaca oleracea extract; risperidone, article; controlled study; drug efficacy; human; major clinical study; positive syndrome; psychological symptom; randomized controlled trial; schizophrenia; scoring system; symptom
Subjects: WM Psychiatry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Psychiatry
Faculty of Nursing and Midwifery
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Reserach Vice-Chancellar Department > student research center
Depositing User: zahra bagheri .
Date Deposited: 09 Aug 2017 05:45
Last Modified: 15 Apr 2018 05:25
URI: http://eprints.skums.ac.ir/id/eprint/2733

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