Effect of ethanolic extract of green tea (Camellia sinensis) on intra-abdominal adhesions in rats

Asadi, Seyed Yazdan. and Parsaei, Pouya. and Karimi, Mehrdad. and Rafieian-Kopaei, Mahmoud. (2013) Effect of ethanolic extract of green tea (Camellia sinensis) on intra-abdominal adhesions in rats. Journal of Zanjan University of Medical Sciences and Health Services, 21 (86). pp. 86-96.


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Background and Objective: Adhesion bands comprise the most important unpleasant consequences of pelvic surgeries. Green tea (Camellia sinensis), due to its anti-oxidant and anti-inflammatory effects and prevention of production and accumulation of collagen seems to be beneficial in this event. Therefore, the present study was designed to elicit he effect of alcoholic extract of green tea on intra-abdominal adhesions. Materials and ethods: In this experimental study 30 healthy male Wistar rats were randomly assigned to two equal groups; one group taking green tea (A) and the other group taking normal aline (B). After anesthesia, their abdominal wall was opened, three longitudinal and ransverse incisions of 2 cm in length were made on the right side of peritoneal surface and a 2×2 cm piece of the left abdominal wall peritoneum was removed. Then, 4 ml green tea extract or normal saline was introduced into the abdominal cavity of the rats. Two weeks later in the second laparotomy, the adhesions were graded according to the strength, extent and appearance. Data were analyzed by Mann-Whitney test, using SPSS v.16. Results: There were significant differences between the scores of groups A and B (P=0.001). The median adhesion scores were 3 and 8 in groups A and B, respectively. Conclusion: The results of this study provide the evidence that green tea extract has a potential capacity to effectively prevent postoperative intra abdominal adhesions in rats and might be beneficial during clinical surgeries.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: green tea extract, abdominal wall; animal experiment; article; controlled study; drug efficacy; experimental study; incision; laparotomy; male; nonhuman; peritoneum adhesion; rat; tea
Subjects: WO Surgery
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Surgery
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 09 Aug 2017 05:51
Last Modified: 15 Apr 2018 04:16
URI: http://eprints.skums.ac.ir/id/eprint/2732

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