In-vitro effect of menthe piperita and salvia officinalis extracts on trichomonas vaginalis

Yousefi, Morteza. and Taghipur, Simin. and Arefkhah, Nasir. and Rahimian, Razieh. and Davoudian, Azadeh. and Rafieian-Kopaei, Mahmoud. and Yousefi darani, Hossein. (2013) In-vitro effect of menthe piperita and salvia officinalis extracts on trichomonas vaginalis. Journal of Isfahan Medical School, 31 (240). pp. 811-818.


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Background: Trichomonas vaginalis is a flagellate parasite causing vaginosis, a common sexual transmitted disease. Metronidazole is the drug of choice for this disease but due to its side effects, it is necessary to search for an alternative drug. In this study, the effect of Menthe piperita and Salvia officinalis on Trichomonas vaginalis was investigated. Methods: Hydro-alcoholic extracts of the two herbs were prepared. The extracts were dried using vacuum rotary evaporator. Different concentrations of the extracts in comparison with methronidazole were added in test tubes containing culture medium and the parasite. All test tubes were kept in 37°C for 24 hours. The tubes were then expected for the parasite growth. Findings: In concentrations of 2, 2.5, 4, 5, 8, and 10 mg/ml of Salvia officinalis and in concentrations of 4, 5, 8, and 10 mg/ml of Menthe piperita the parasite did not grow. The effect of the extracts on Trichomonas vaginalis was similar to the effect of metronidazole on the parasite. Conclusion: Salvia officinalis and Menthe piperita had efficient effect against Trichomonas vaginalis growth in culture medium and s,o these two herbs can be considered as alternatives drugs. However, more investigation is recommended.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: metronidazole; peppermint; Salvia officinalis extract, article; culture medium; human; trichomoniasis
Subjects: WP Gynecology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine
Faculty of Medicine > Basic Sciences Academic Groups > Department of Parasitology and Mycology
Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 09 Aug 2017 07:00
Last Modified: 28 Feb 2018 05:41

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