Effect of hydro-alcoholic extract of Ziziphus jujuba on the peripheral blood cells in Balb/c mice

Ahmad Abadi, M.N. and Hojjati, M.R. and Sedighi, M. (2013) Effect of hydro-alcoholic extract of Ziziphus jujuba on the peripheral blood cells in Balb/c mice. Physiology and Pharmacology, 17 (2). pp. 224-230.

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Abstract

Introduction: In the Iranian traditional medicine, Ziziphus jujuba is recommended for treatment of anemia, but no investigation has addressed this issue. In the present study, the effect of hydro-alcoholic extract of this plant was evaluated on the peripheral blood cells in male Balb/c mice. Methods: Hydro-alcoholic extract was prepared from the fruits of the Ziziphus jujuba. Male mice were injected with normal saline or the extract (100, 200 or 400 mg/kg, i.p.) for a period of two weeks. Afterwards, the mice were anesthetized and blood samples were taken from their hearts and then the peripheral blood was evaluated by a Cell Counter apparatus. White blood cells differential analysis was manually performed under a microscope. Data was statistically analyzed using One-way ANOVA followed by Tukey post-hoc test. Results: Ziziphus jujuba extracts (100 and 400 mg/kg) caused a significant reduction in the percentages of monocytes and neutrophils, respectively (P<0.05). At a dose of 400 mg/kg, Ziziphus jujuba extract increased the percentage of lymphocytes (P<0.05). However, no significant changes were observed in the amounts of WBC, RBC, platelets, hemoglobin, Hct, MCV, MCH and MCHC in the extract-treated groups (P>0.05). Conclusion: Findings of this study show that Ziziphus jujuba extract increases the percentage of lymphocytes and also reduces the percentage of monocytes and neutrophils.

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