Selenium and leptin levels in febrile seizure: A case-control study in children

Khoshdel, Abolfazl. and Parvin, Neda. and Abbasi, Maedeh. (2013) Selenium and leptin levels in febrile seizure: A case-control study in children. Korean Journal of Pediatrics, 56 (2). pp. 80-85.

[img]
Preview
Text
22.pdf

Download (860kB) | Preview
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Purpose: Febrile seizures (FS) are seizures that occur between the age of 6 and 60 months, but its pathophysiology still is not fully understood. There is limited information about the correlation between levels of selenium and leptin with FS. This study aimed to determine the relationship between serum levels of selenium and leptin in children with FS. Methods: This case-control study was conducted in a University Hospital in Shahrekord, Iran, in 2011. The serum levels of selenium and leptin of 25 children with simple febrile seizure (case group) were compared with 25 febrile children without seizure (control group) in acute phase and after three months. The levels of serum selenium and leptin were measured by flame atomic absorption spectrophotometer and enzyme-linked immunosorbent assay method, respectively. Results: In acute phase, the mean serum level of selenium in case and control groups were 95.88± 42.55 and 113.25±54.43 μg/dL, respectively, and difference was not significant (P =0.415), but after three months, this level had a significant increase in both groups (P<0.001). In acute phase, the mean serum leptin level in case and control groups were 0.94±0.5 and 0.98±0.84 ng/mL, respectively, but difference was not significant (P=0.405). After three months, serum leptin level had no significant change in both groups (P =0.882). Conclusion: These observations suggest that serum levels of selenium and leptin have not specific relation with FS but overllay is lower, however, further study is recommended. Also selenium level in stress and acute phase was significantly lower than recovery phase. © 2013 by The Korean Pediatric Society.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: leptin; selenium, article; blood sampling; case control study; child; clinical article; controlled study; drug blood level; enzyme linked immunosorbent assay; febrile convulsion; female; flame photometry; follow up; human; male; preschool child
Subjects: WL Nervous system
WS Pediatrics
Divisions: Faculty of Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Pediatrics
Faculty of Nursing and Midwifery
Depositing User: zahra bagheri .
Date Deposited: 09 Aug 2017 05:55
Last Modified: 17 Feb 2018 08:25
URI: http://eprints.skums.ac.ir/id/eprint/2709

Actions (login required)

View Item View Item