Efficacy of Co-Administration of garlic extract and metformin for prevention of gentamicin-renal toxicity in wistar rats: A biochemical study

Rafieian-Kopaei, Mahmoud. and Baradaran, Azar. and Merrikhi, Alireza. and Nematbakhsh, Mehdi. and Madihi, Yahya. and Nasri, Hamid. (2013) Efficacy of Co-Administration of garlic extract and metformin for prevention of gentamicin-renal toxicity in wistar rats: A biochemical study. International Journal of Preventive Medicine, 4 (3). pp. 258-264.

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Abstract

Background: Gentamicin (GM) nephrotoxicity has been related to oxidative stress. Garlic and metformin (MF) have anti-oxadant activity and therefore, this study was aimed to evaluate the preventive and curative effects of garlic, MF and their combination on GM indeced tubular toxicity in Wistar rats. Methods: In a pre-clinical study, 70 male Wistar rats were randomly designated into 7 groups of 10 and treated as follows: Group 1: Received saline for 20 days. Group 2: Were injected 100 mg/kg/d of GM intraperitoneally (ip), for 10 days and saline for 10 more days. Group 3: Received GM for 10 days then 20 mg/kg garlic ip for the next 10 days. Group 4: Received GM for 10 days and MF (100 mg/kg) orally for the next 10 days. Group 5: Received GM for 10 days and a combination of MF and garlic for the next 10 days (100 and 20 mg/kg, respectively). Group 6: The same as group 5but with half-doses of MF and Garlic. Group 7: Received GM for 10 days together with a combination ofMF and garlic. On 20th day of the experiment the serum blood urea nitrogen (BUN) and creatinine (Cr) were measured and compared in different groups. Results: GM injection significantly increased the serum BUN and Cr (P < 0.05). Administration of MF, garlic or their combination with or after injection of GM (high doses) could atenuate BUN and Cr. Conclusions: The results indicate that MF and garlic or their combination have curative and protective activity against GM nephrotoxicity.

Item Type: Article
Additional Information: cited By 65
Uncontrolled Keywords: allicin; creatinine; flavonoid; garlic extract; gentamicin; metformin; nitrogen; phenol derivative; sodium chloride; urea, animal experiment; animal model; animal tissue; antioxidant activity; article; controlled study; creatinine blood level; drug effect; drug efficacy; male; nephrotoxicity; nonhuman; rat; urea nitrogen blood level; Wistar rat
Subjects: WJ Urogenital System
QV pharmacology > QV 600 Toxicology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 09 Aug 2017 05:22
Last Modified: 11 Jun 2018 05:29
URI: http://eprints.skums.ac.ir/id/eprint/2693

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