Differential consequences of unilateral nasal air-puff stimulation on breathing pattern and respiratory system mechanics in tracheotomized rats

Bakhshesh, M. and Heidarian, E. and Abdolkarimi, A. and Alizadeh, S. and Karimian, M. (2013) Differential consequences of unilateral nasal air-puff stimulation on breathing pattern and respiratory system mechanics in tracheotomized rats. Iranian Journal of Basic Medical Sciences, 16 (2). pp. 116-122.


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Objective(s): Reflexes that rose from mechanoreceptors in nasal cavities have extensive neuro-regulatory effects on respiratory system. Because of side specific geometry and dual innervations of the nasal mucosa, we investigated the consequences of unilateral nasal stimulations on respiratory mechanics and breathing patterns. Materials and Methods: Unilateral nasal air-puff stimulation (30 min) in the presence of propranolol (5 mg/kg) and atropine (5 mg/kg) were applied on tracheotomized spon-taneously breathing rats. Breathing rate and pattern monitored. Peak inspiratory pres-sure (PIP) and flow (PIF) were exploited for calculation of resistance, dynamic compli-ance (Cdyn), and estimation of respiratory system impedance (Zrs). Results: During right-side stimulation, in propranolol (P<0.05) and atropine groups (P<0.01) PIP significantly decreased in comparison to the control group. Alternatively, it significantly increased in left-side and propranolol-left groups (P<0.05) than control group. Mean Cdyn following left-side stimulation and propranolol, revealed significant decrements (P<0.05) than control group. In the case of atropine-right and atropine-left groups, mean Cdyn had significantly decreased in comparison with atropine alone (P<0.05). Airway resistance (R) did not reveal significant difference during nasal stimula-tions whereas least square approximation revealed a significant side-specific frequency dependent deviation of imaginary part of impedance (X). An inverse correlation was de-termined for Cdyn versus frequency following right side (R=-0.76) and left side (R=-0.53) stimulations. Conclusion: For the reason that lower airways mechanics changed in a way independent from smooth muscle, it may be concluded from our data that unilateral nasal stimula-tions exert their different controls through higher regulatory centers. © 2013 mums.ac.ir All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: atropine; propranolol, airway dynamics; airway resistance; animal experiment; animal model; article; artificial ventilation; blood pressure; breathing mechanics; breathing pattern; controlled study; electrocardiography; mechanoreceptor; nonhuman; rat; tracheotomy
Subjects: WF Respiratory System
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: Users 1 not found.
Date Deposited: 09 Aug 2017 05:17
Last Modified: 09 Aug 2017 05:17
URI: http://eprints.skums.ac.ir/id/eprint/2691

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