Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits

Setorkil, Mahboobeh. and Rafieian-Kopaei, Mahmoud. and Merrikhi, Alireza. and Heidarian, Esfandiar and Shahin Fard, Najmeh. and Ansari Samani, Roya. and Nasri, Hamid. and Esmael, Nafiseh. and Baradaran, Azar. (2013) Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits. International Journal of Preventive Medicine, 4 (8).

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Abstract

Background: We aimed to determine the effects of Anethum graveolens (Dill) powder on postprandial lipid profile, markers of oxidation and endothelial activation when added to a fatty meal. Methods: In an experimental study, 32 rabbits were randomly designated into four diet groups: normal diet, high cholesterol diet (1), high cholesterol diet plus 5 (w/w) dill powder and high cholesterol diet plus lovastatin (10 mg/kg, bw). The concentrations of glucose, total cholesterol (TC), low-density lipoproteins-cholesterol (LDL-C), alanine aminotransferase (alt), aspartate aminotransferase (ast), fibrinogen, factor VII, apolipoprotein B (ApoB), nitrite and nitrate were measured in blood samples following 15 h of fasting and 3 h after feeding. Results: Concurrent use of A. graveolens powder or lovastatin significantly decreased ALT, TC, glucose, fibrinogen and LDL-C values in comparison with hypercholesterolemic diet group (P < 0.05). Consumption of A. graveolens or lovastatin did not change factor VII, ApoB, nitrite and nitrate levels significantly in comparison with hypercholesterolemic diet group. Intake of A. graveolens significantly decreased serum AST compared to hypercholesterolemic diet. Conclusions: A. graveolens might have some protective values against atherosclerosis and that it significantly affects some biochemical risk factors of this disease. Our findings also confirm the potential harmful effects of oxidized fats and the importance of dietary polyphenols in the meal.

Item Type: Article
Additional Information: cited By 34
Uncontrolled Keywords: alanine aminotransferase; Anethum graveolens extract; anthocyanin; apolipoprotein B; aspartate aminotransferase; blood clotting factor 7; cholesterol; fatty acid; fibrinogen; flavonoid; glucose; lipid; low density lipoprotein cholesterol; mevinolin; nitrate; nitrite; phenol; plant extract; unclassified drug, alanine aminotransferase blood level; animal experiment; animal model; antioxidant activity; article; aspartate aminotransferase blood level; atherosclerosis; blood sampling; cell activation; cholesterol blood level; cholesterol diet; combination chemotherapy; controlled study; diet restriction; dill; drug determination; endothelial activation; experimental rabbit; feeding; fibrinogen blood level; glucose blood level; health impact assessment; hypercholesterolemia; lipid analysis; lipid diet; lipid oxidation; male; nonhuman; outcome assessment; physical chemistry; postprandial state; powder; protein blood level; therapy effect
Subjects: WG Cardiovascular System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 09 Aug 2017 04:27
Last Modified: 30 May 2018 08:21
URI: http://eprints.skums.ac.ir/id/eprint/2668

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