In-vitro effect of hydro-alcoholic extract of Tanacetum parthenium extract on Trichomonas vaginalis

Arefkhah, Nasir. and Taghipur, Simin. and Yousefi, Morteza. and Rafieian-Kopaei, Mahmoud. and Daneshpur, Shima. and Yousefi darani, Hossein. (2013) In-vitro effect of hydro-alcoholic extract of Tanacetum parthenium extract on Trichomonas vaginalis. Journal of Isfahan Medical School, 31 (236).

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Abstract

Background: Trichomonas vaginalisis a flagellate parasite causing vaginosis as a common sexual transmitted disease. Metronidazole is the drug of choice for this disease; but due to its side effects it is necessary to search for an alternative drug. In this study, the effect of Tanacetum parthenium on Trichomonas vaginalis was investigated. Methods: Using percolation method, hydro-alcoholic extracts of Tanacetum parthenium was prepared. The extract was dried using vacuum rotary evaporator. Different doses of the extract were added to 8 tubes containing culture medium of Trichomonas vaginalis; metronidazole was added to 1 tube. Finally, 104 Trichomonas vaginalis was added to each tube. Every 24 hours for 3 days, the tubes were seen for count and motion of the parasite under the microscope. Findings: In concentrations of 4, 5, 8 and 10 mg/ml of Tanacetum parthenium, the parasite did not grow. The effect of the extract on Trichomonas vaginalis was similar to the effect of metronidazole. Conclusion: Tanacetum parthenium has efficient effect against Trichomonas vaginalis growth in culture medium; so, this herb can be considered as alternative drug for methronidazole.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: metronidazole; Tanacetum parthenium extract; Tanacetum parthenium extract, article; controlled study; culture medium; growth inhibition; microscopy; nonhuman; parasite cultivation; solvent extraction; Trichomonas vaginalis; microscope; percolation; procedures
Subjects: WC Communicable Diseases > Tropical and parasitic Diseases
WP Gynecology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Parasitology and Mycology
Reserach Vice-Chancellar Department > student research center
Depositing User: zahra bagheri .
Date Deposited: 08 Aug 2017 10:00
Last Modified: 28 Feb 2018 05:39
URI: http://eprints.skums.ac.ir/id/eprint/2659

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