Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals

Asgary, Sedigheh. and Keshvari, Mahtab. and Sahebkar, Amirhossein. and Hashemi, Mohammad. and Rafieian-Kopaei, Mahmoud. (2013) Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals. ARYA Atherosclerosis, 9 (6). pp. 326-331.

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Abstract

BACKGROUND: Pomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of PJ consumption on blood pressure and markers of endothelial function. METHODS: In this single-arm study, thirteen hypertensive men aged 39-68 years were recruited. Included subjects were assigned to natural PJ (150 ml/day) following a 12 hour fast. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and flow-mediated dilation (FMD), along with serum concentrations of C-reactive protein (CRP), intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin and interleukin-6 (IL-6) were measured at baseline and 4-6 hours after PJ consumption. RESULTS: Comparison of pre- vs. post-trial values revealed a significant reduction in both SBP (7; P = 0.013) and DBP (6; P < 0.010). However, changes in FMD (20) as well as circulating levels of CRP, ICAM-1, VCAM-1, E-selectin, and IL-6 did not reach statistical significance (P = 0.172). CONCLUSION: PJ has promising acute hypotensive properties. Consumption of PJ could be considered in the context of both dietary and pharmacological interventions for hypertension.

Item Type: Article
Additional Information: cited By 31
Uncontrolled Keywords: anthocyanin, adult; aged; article; blood pressure; blood sampling; cardiovascular function; chemical analysis; clinical article; clinical trial; diastolic blood pressure; endothelial function; female; human; hypertension; male; pomegranate juice; systolic blood pressure
Subjects: WG Cardiovascular System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 08 Aug 2017 07:28
Last Modified: 24 Jul 2018 06:29
URI: http://eprints.skums.ac.ir/id/eprint/2614

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