Low dose tranexamic acid effect on post-coronary artery bypass grafting bleeding

Esfandiari Bakhtiari, Rostam. and Moazeni Bistgani, Mohammad. and Kabiri, Majid. (2013) Low dose tranexamic acid effect on post-coronary artery bypass grafting bleeding. Asian Cardiovascular and Thoracic Annals, 21 (6). pp. 669-674.


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Objective: This study investigated the effects of low-dose tranexamic acid on post-coronary artery bypass surgery bleeding. Background: Diffuse microvascular bleeding is still a common problem after cardiac procedures. This study was designed to evaluate the hemostatic effects of low-dose tranexamic acid in on-pump coronary artery bypass graft surgery. Methods: In this prospective randomized placebo-controlled study, 150 patients who were candidates for coronary artery bypass were enrolled and randomly assigned to 1 of 2 groups (tranexamic acid or placebo). Total drainage volume and the need for transfusion as well as surgical complications were recorded and compared in the 2 groups. Results: There was significantly less mediastinal chest tube drainage up to 48 h in the tranexamic acid group (432±210 mL) compared to the placebo group (649±235 mL, p=0.006). In the placebo group, 43 (58) patients were given allogeneic blood during hospital stay compared to 22 (25) in the tranexamic acid group (p<0.001). No significant difference in postoperative complications was seen. Conclusion: The use of low-dose tranexamic acid can significantly reduce blood loss and need for transfusion, with no increase in complications. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: placebo; tranexamic acid, acute kidney tubule necrosis; adult; allogeneic blood transfusion; blood transfusion; cerebrovascular accident; controlled study; coronary artery bypass graft; dose response; drug efficacy; female; heart infarction; hemostasis; human; low drug dose; major clinical study; male; outcome assessment; pericardial effusion; postoperative complication; postoperative hemorrhage; prospective study; randomized controlled trial; reoperation; review; surgical mortality; systemic therapy; thorax drainage, Antifibrinolytic agents; blood transfusion; coronary artery bypass; postoperative hemorrhage; tranexamic acid, Adult; Aged; Antifibrinolytic Agents; Blood Transfusion; Cardiopulmonary Bypass; Chest Tubes; Coronary Artery Bypass; Drainage; Female; Humans; Iran; Male; Middle Aged; Postoperative Hemorrhage; Prospective Studies; Time Factors; Tranexamic Acid; Treatment Outcome
Subjects: WG Cardiovascular System
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Anesthesiology
Faculty of Medicine > Department of Clinical Sciences > Department of Cardiology
Depositing User: Users 1 not found.
Date Deposited: 08 Aug 2017 06:06
Last Modified: 06 Mar 2018 10:00
URI: http://eprints.skums.ac.ir/id/eprint/2590

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