ASSOCIATION OF THE VIRULENCE FACTORS OF HELICOBACTER PYLORI AND GASTRIC MUCOSAL INTERLEUKIN-17/23 MRNA EXPRESSION IN DYSPEPTIC PATIENTS

Bagheri, Nader. and Rahimian, Ghorbanali. and Salimzadeh, Loghman. and Azadegan-Dehkordi, Fatemeh. and Rafieian-Kopaei, Mahmoud. and Taghikhani, Afshin. and shirzad, Hedayatollah. (2013) ASSOCIATION OF THE VIRULENCE FACTORS OF HELICOBACTER PYLORI AND GASTRIC MUCOSAL INTERLEUKIN-17/23 MRNA EXPRESSION IN DYSPEPTIC PATIENTS. EXCLI JOURNAL, 12. pp. 5-14.

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Abstract

The molecular pathways that control Helicobacter pylori (Hp)-associated inflammatory reaction are complex, but locally induced cytokines and virulence factors seem to have a major role in maintaining the ongoing inflammation. Therefore this study was aimed to evaluate the association of the virulence factors of Hp and gastric mucosal interleukin-17/23 mRNA expression in dyspeptic patients. Mucosal IL-17 and IL-23 mRNA expression in H. pylori infected and non-infected gastric biopsies were determined by real-time RT-PCR. Virulence factors, vac-A and cag-A were evaluated using PCR. There was no significant difference in mucosal IL-17 and IL-23 mRNA expression between H. pylori infected and non-infected patients. Their expression in mucosa did not correlate with chronic gastritis and chronic active gastritis. IL-17 and IL-23 mRNA expression in mucosa of patients with vacA m1 were significantly higher than those observed in patients with vacA m2. The severity of polymorphonuclear infiltration and chronic active gastritis was higher in cag-A positive than cag-A negative patients. H. pylori infections carrying the vacA m1 allele have higher IL-17 and IL-23 mRNA and the current study suggests that the virulence factor vacA allele's m1 are important for the severe gastric inflammation.

Item Type: Article
Uncontrolled Keywords: H. pylori; virulence factor; interleukin; gastritis
Subjects: WI Digestive System
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 08 Aug 2017 05:20
Last Modified: 31 Jan 2018 05:19
URI: http://eprints.skums.ac.ir/id/eprint/2576

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