Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat

Asadi, Seyed Yazdan. and Parsaei, Pouya. and Karimi, Mehrdad. and Ezzati, Sareh. and Zamiri, Alaleh. and Mohammadizadeh, Fereshteh. and Rafieian-Kopaei, Mahmoud. (2013) Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat. INTERNATIONAL JOURNAL OF SURGERY, 11 (4). pp. 332-337.


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Green tea (Camellia sinensis) has anti-oxidant and anti-inflammatory properties and may enhance wound healing process. The present study, therefore, was aimed to examine the effect of green tea ethanolic extract on wound healing process. For this experimental study, 36 healthy male Wistar rats were randomly designated to three groups of A, B, and C which, respectively treated with, Vaseline + 0.6% green tea extract, Vaseline and normal saline for 21 days. Wounds' length and area were measured by caliper every other day and specimens were taken at 3rd, 12th, and 21st day for microscopical examinations. Data were analyzed by SPSS 16 using survival analysis (Breslow test), repeated measured ANOVA, one-way ANOVA and Mann-Whitney. P < 0.05 was considered as statistically significant. The mean healing duration of surgical wounds in groups A and B was 14.66 and 20.66 (P = 0.018), respectively. Decrease in healing duration in the group A was significantly higher within the first two weeks compared with control groups (P 0.05). Microscopic examinations also indicated a significant difference in wound healing process between groups A and C throughout the whole study duration as well as groups A and B during the 3rd week of the study (P < 0.05). Green tea extract could help wound healing process, probably effective on surgical wounds healing. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Green tea; Camellia sinensis; Healing process; Surgical wound; Rat
Subjects: WO Surgery
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Surgery
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 08 Aug 2017 04:37
Last Modified: 23 Jul 2018 07:37
URI: http://eprints.skums.ac.ir/id/eprint/2571

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