Significance of extracapillary proliferation in IgA-nephropathy patients with regard to clinical and histopathological variables

Rafieian-Kopaei, M. and Baradaran, A. and Nasri, H. (2013) Significance of extracapillary proliferation in IgA-nephropathy patients with regard to clinical and histopathological variables. HIPPOKRATIA, 17 (3). pp. 258-261.

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Abstract

Background and Aim: Extracapillary proliferation (crescent) was not included in the Oxford classification, although previous attempts to correlate the crescent with clinical outcomes have produced conflicting results. In this study, we investigated the clinical and morphological significance of extracapillary proliferation in a group of IgA nephropathy (IgAN) patients with regard to the Oxford classification. Patients and Methods: In an observational study conducted on IgAN patients, we collected a total of 114 biopsies. We diagnosed IgAN by light and immunofluorescence for all patients. Results: Of the 114 patients, 70.2% were male. The mean age of the patients was 37.7 +/- 13.6 years. The mean proteinuria was 1742 +/- 1324 mg/ day. The mean serum creatinine was 1.6 +/- 1.5 mg/dL. Twenty-five (21.9%) patient kidney biopsies had extracapillary proliferation. We found a significant positive correlation between the number of crescents and serum creatinine (p< 0.001). Furthermore, we found a positive association between the nephrotic syndrome and the total number of crescents (p< 0.05). Additionally, we observed a significant positive correlation between the amount of sclerosed glomeruli and extracapillary proliferation (p= 0.028). Conclusion: Our findings confirm that extracapillary proliferation has a significant association with proteinuria and sclerotic glomeruli. We anticipate that extracapillary proliferation will be included in a revision of the Oxford classification of IgAN to widen the scope of the classification.

Item Type: Article
Uncontrolled Keywords: IgA nephropathy; nephrotic syndrome; Oxford classification; endocapillary proliferation; crescent; endstage; renal disease; proteinuria
Subjects: WJ Urogenital System
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 08 Aug 2017 03:49
Last Modified: 08 Aug 2017 03:49
URI: http://eprints.skums.ac.ir/id/eprint/2562

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