Bright Renoprotective Properties of Metformin Beyond Blood Glucose Regulatory Effects

Nasri, Hamid. and Baradaran, Azar. and Ardalan, Mohammadreza. and Mardani, Saeed. and Momeni, Ali. and Rafieian-Kopaei, Mahmoud. (2013) Bright Renoprotective Properties of Metformin Beyond Blood Glucose Regulatory Effects. IRANIAN JOURNAL OF KIDNEY DISEASES, 7 (6). pp. 423-428.


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Metformin, a biguanide drug, is widely prescribed to treat high blood glucose in individuals with type 2 diabetes mellitus. Type 2 diabetes mellitus is a troubling chronic disease and diabetic nephropathy is one of the most important complications of diabetes mellitus. Recent studies suggest that metformin, in addition to its efficacy in treating type 2 diabetes, may also have therapeutic efficacy in other conditions, including diabetic nephropathy or ameliorative property against tubular cell injury. Moreover, metformin significantly decreases albuminuria in patients with type 2 diabetes mellitus. However, the exact mechanisms beyond the effect of metformin on blood glucose are still unknown. Recent studies suggest that the therapeutic effect of metformin is mediated by its action on adenosine monophosphate-activated protein kinase in tissues. Various investigations show that metformin decreases intracellular reactive oxygen species. Metformin protects against tubular injury by restoring the biochemical alterations and regulation of oxidative stress on renal tubules. It also protects podocytes in nephropathy of diabetes. These findings can more strongly potentiate the clinical use of metformin in the prevention of nephropathy of diabetes. In this regard, to better understand the metformin nephroprotective properties, more experimental rat models and clinical studies are needed.

Item Type: Article
Uncontrolled Keywords: metformin; diabetic nephropathy; oxidative stress
Subjects: WH Hemic and Lymphatic System
QV pharmacology > QV 704 Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 07 Aug 2017 08:10
Last Modified: 12 Jun 2018 10:26

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