Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial.

Nasri, Hamid. and Behradmanesh, Saeed. and Maghsoudi, Ahmad Reza. and Ahmadi, Ali. and Nasri, Parto. and Rafieian-Kopaei, Mahmoud. Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial.

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Abstract

INTRODUCTION Studies have revealed the association between vitamin D deficiency and changes in blood glucose and insulin levels as well as sensitivity of the target tissues to insulin. OBJECTIVE In this study, we examined the effect of adding vitamin D (cholecalciferol ; 50,000 units) to therapeutic regimen of T2DM patients compared to placebo on regulating the blood glucose and glycemic parameters. PATIENTS AND METHODS This study was a double blind clinical trial conducted on 60 type 2 diabetes mellitus (T2DM) patients. Exclusion criteria were taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin D metabolism in the past 6 months. Serum 25-Hydroxy vitamin D [25(OH)D] level was measured with ELISA method. Patients were administered weekly vitamin D supplementation (50000 units) for 12 weeks. RESULTS There was no significant relation between HbA1c and 25(OH)D level prior the study (p> 0.05). After intervention, 25(OH)D level in interventional group was significantly higher compared to that of control group. HbA1c in male interventional group was significantly less than that of control group (p= 0.0068). CONCLUSION Weekly vitamin D supplementation had beneficial effect on glycemic parameters in male type 2 diabetic patients.

Item Type: Article
Subjects: WD Nutrition Disease and metabolic diseases
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 06 Aug 2017 06:30
Last Modified: 30 May 2018 08:18
URI: http://eprints.skums.ac.ir/id/eprint/2418

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