Protective effect of Kombucha tea on liver damage induced by thioacetamide in rats

Kabiri, najmeh. and Ahangar Darabi, Mahboobeh. and Rafieian-Kopaei, Mahmoud. and Setorki, Mahbubeh. and Doudi, Monir. (2014) Protective effect of Kombucha tea on liver damage induced by thioacetamide in rats. Journal of Biological Sciences, 14 (5). pp. 343-348.


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The aim of this study is to evaluate the possible protective effects of Kombucha tea against thioacetamide induced liver damage in rats. A total of 24 male Wistar rats were divided into four groups: Control, treated with thioacetamide (TAA) treated with TAA and then Kombucha tea, treated with Kombucha tea and then TAA; following 3 weeks of treatment. All the animals were killed and liver tissue samples were obtained for histopafhological investigation. The data showed that TAA significantly increased aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) but not bilirubin. The treatment by Kombucha tea promoted a significant reduction in serum enzyme levels AST, ALT, ALP, LDH and reduction in bilirubin content. The results show that the Kombucha tea has protective effects against the thioacetamide induced hepatotoxicity that might be due to antioxidant activities of these plants. © 2014 Asian Network for Scientific Information.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; cholesterol; high density lipoprotein; lactate dehydrogenase; low density lipoprotein; thioacetamide; triacylglycerol, animal experiment; animal model; animal tissue; article; body weight; colorimetry; controlled study; enzyme blood level; experimental liver injury; histopathology; kombucha tea; liver protection; liver weight; male; nonhuman; rat; severe hepatic impairment; tea
Subjects: WK Endocrine System
QU Biochemistry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 05 Aug 2017 07:29
Last Modified: 06 Mar 2018 10:10

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