The protective effects of Ziziphus vulgaris L. Fruits on biochemical and histological abnormalities induced by diabetes in rats

Goli-Malekabadi, N. and Asgary, S. and Rashidi, B. and Rafieian-Kopaei, M. and Ghannadian, M. and Hajian, S. and Sahebkar, A. (2014) The protective effects of Ziziphus vulgaris L. Fruits on biochemical and histological abnormalities induced by diabetes in rats. Journal of Complementary and Integrative Medicine, 11 (3). pp. 171-177.

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Abstract

Background: Diabetes mellitus arises from a deficient production and action of insulin. Ziziphus vulgaris L. (jujube) is a medicinal plant that is known to have antidiabetic actions. The aim of the present study was to investigate the protective effects of jujube fruit powder and extract against biochemical imbalances in stereptozotocin (STZ)-induced diabetes. Methods: Diabetes was induced in rats using intraperitoneal injection of STZ at a dose of 60 mg/kg body weight (bw). Jujube powder (1 g/kg bw) and extract (1 g/kg bw) were administered daily via gavage, from two weeks prior to three weeks after STZ injection. Serum concentrations of glucose, insulin, and lipids and histological changes of the pancreas tissue were assessed at the end of study. Results: The kaempferol content of jujube extract was found to be 0.013±0.0005 (w/w). Two weeks of supplementation with jujube powder resulted in a significant reduction of serum glucose levels compared with the non-diabetic control group prior to STZ treatment. Both jujube preparations prevented serum insulin decrease following STZ treatment, increased antioxidant capacity, and reduced total cholesterol, high-density lipoprotein cholesterol, triglycerides, and malondialdehyde levels. Jujube powder reduced serum low-density lipoprotein cholesterol and C-reactive protein concentrations while jujube extract had no effect on these parameters. Histopathological examination revealed a significant attenuation of pancreatic inflammation in the jujube-treated animals. Conclusions: The present findings suggest a protective role of jujube supplementation, in particular in the powdered form, against diabetes-induced biochemical and histopathological abnormalities. © 2014 Walter de Gruyter GmbH, Berlin/Boston.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: antidiabetic agent; antioxidant; C reactive protein; cholesterol; hemoglobin A1c; high density lipoprotein; jujube extract; kaempferol; low density lipoprotein cholesterol; malonaldehyde; triacylglycerol; unclassified drug; Ziziphus vulgaris extract; antidiabetic agent; antioxidant; C reactive protein; glucose blood level; insulin; kaempferol derivative; lipid; malonaldehyde; plant extract; powder, adult; animal experiment; animal model; animal tissue; antidiabetic activity; antioxidant activity; Article; blood level; body weight; cell protection; chemical analysis; cholesterol blood level; control group; controlled study; diabetes mellitus; diet supplementation; enzyme blood level; fruit; glucose blood level; histopathology; insulin blood level; jujube; lipid blood level; lipoprotein blood level; male; medicinal plant; nonhuman; pancreas; pancreatitis; powder; rat; streptozotocin-induced diabetes mellitus; triacylglycerol blood level; Ziziphus vulgaris; animal; blood; chemistry; Diabetes Mellitus, Experimental; drug effects; fruit; inflammation; metabolism; pathology; phytotherapy; Wistar rat; Ziziphus, Animals; Antioxidants; Blood Glucose; C-Reactive Protein; Diabetes Mellitus, Experimental; Fruit; Hypoglycemic Agents; Inflammation; Insulin; Kaempferols; Lipids; Male; Malondialdehyde; Pancreas; Phytotherapy; Plant Extracts; Powders; Rats, Wistar; Ziziphus
Subjects: WD Nutrition Disease and metabolic diseases
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 05 Aug 2017 06:58
Last Modified: 05 Aug 2017 06:58
URI: http://eprints.skums.ac.ir/id/eprint/2331

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