Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats

Asgary, S. and Rafieian-Kopaei, M. and Shamsi, F. and Najafi, S. and Sahebkar, A. (2014) Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats. Journal of Complementary and Integrative Medicine, 11 (2). pp. 63-69.

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Abstract

Background: Anthocyanins are phytochemicals with a multitude of pharmacological actions including anti-diabetic and anti-hyperlipidemic effects. This study was undertaken to evaluate the anti-hyperglycemic and antihyperlipidemic effects of cornelian cherry (Cornus mas L., CM) fruits - that are rich in anthocyanins and known to have medicinal properties- in alloxan-induced diabetic rats. Methods: Twenty-eight adult male rats were randomly assigned to four groups of seven animals each: non-diabetic control, diabetic control, glibenclamide-treated (0.6 mg/kg/day; 4 weeks) and CM fruit-treated (2 g/day; 4 weeks) group. Diabetes was induced by a single injection of alloxan (120 mg/kg). Fasting serum levels of glucose, total cholesterol (TC), low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), aspartate (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured at the end of study period. Results: Diabetic rats had significantly elevated levels of serum glucose, LDL-C, TG, AST, ALP and ALT and decreased levels of HDL-C compared to the non-diabetic group (p < 0.05). Treatment with either glibenclamide or CM counterbalanced the above-mentioned abnormalities. The effects of CM were comparable to those of glibenclamide at the doses tested in this study. Serum glucose, TG, ALP and HDL concentrations in the normal group were significantly changed compared to the diabetic control group (p < 0.05). There were no significant changes in evaluated biochemical parameters between the glibenclamide and CM groups with normal group. Histopathological examinations revealed a less severe hepatic portal inflammation in the CM-treated vs. other study groups. Conclusions: Dietary supplementation with CM fruits effectively prevents the development of diabetes mellitus, dyslipidemia and hepatic inflammation in alloxan-induced diabetes.

Item Type: Article
Additional Information: cited By 38
Uncontrolled Keywords: alanine aminotransferase; alkaline phosphatase; anthocyanin; antidiabetic agent; antilipemic agent; aspartate aminotransferase; aspartic acid; Cornus mas extract; glibenclamide; glucose; high density lipoprotein cholesterol; triacylglycerol; unclassified drug; alkaline phosphatase; alloxan; anthocyanin; antidiabetic agent; antilipemic agent; glibenclamide; glucose blood level; lipid; plant medicinal product, adult; alanine aminotransferase blood level; alkaline phosphatase blood level; alloxan-induced diabetes mellitus; animal experiment; animal model; animal tissue; antidiabetic activity; article; aspartate aminotransferase blood level; chemical analysis; cholesterol blood level; controlled study; Cornus; Cornus mas; diabetes control; diet supplementation; drug mechanism; glucose blood level; histopathology; male; nonhuman; rat; triacylglycerol blood level; animal; blood; chemically induced; chemistry; Cornus; Diabetes Mellitus, Experimental; drug effects; Drug-Induced Liver Injury; Dyslipidemias; fruit; inflammation; liver; metabolism; pathology; phytotherapy; Wistar rat, Alkaline Phosphatase; Alloxan; Animals; Anthocyanins; Blood Glucose; Cornus; Diabetes Mellitus, Experimental; Dietary Supplements; Drug-Induced Liver Injury; Dyslipidemias; Fruit; Glyburide; Hypoglycemic Agents; Hypolipidemic Agents; Inflammation; Lipids; Liver; Male; Phytotherapy; Plant Preparations; Rats, Wistar
Subjects: WD Nutrition Disease and metabolic diseases
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 05 Aug 2017 03:33
Last Modified: 05 Aug 2017 03:33
URI: http://eprints.skums.ac.ir/id/eprint/2290

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