In-Vitro evaluation of hydroalcoholic extract of Allium ampeloprasum on rat ileum contractions

Sedighi Hafshejani, Mehrnoush. and Noori Ahmad Abadi, Mosayeb. and Nasri, Hamid. and Hadi, Molouk. and Rafieian-Kopaei, Mahmoud. (2014) In-Vitro evaluation of hydroalcoholic extract of Allium ampeloprasum on rat ileum contractions. Journal of Isfahan Medical School, 31 (268). pp. 2238-2249.


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Background: Ampeloprasum is traditionally used for gastrointestinal disorders. In this experimental study, the effect of ethanolic extract of Allium ampeloprasum was investigated on the rat ileum contractions. The mechanisms were also evaluated. Methods: In this experimental study, 48 male Wistar rats were randomly designated into six equal groups, including control and cumulative concentrations of Allium ampeloprasum, propranolol, naloxone, L-name, and CaCl<inf>2</inf>. In the day of the experiment, the ileum was dissected and its contractions were recorded in Tyrode solution in an organ bath. To evaluate the mechanisms involved, propranolol, naloxone, or L-name was incubated and the percent of changes in contractions were recorded. Findings: The extract of Allium ampeloprasum dose-dependently reduced the contractions induced by KCl (60 mM) (P < 0.0001); propranolol reversed this effect (P < 0.0010), but L-name and naloxone were not effective. CaCl<inf>2</inf> increased the contractions (P < 0.0010) and the extract reversed this effect. Conclusion: Allium ampeloprasum leaves can affect the ileum contractions through beta adrenoreceptors and voltage-dependent calcium channels and might be used in gastrointestinal disorders.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Allium Ampeloprasum extract; beta adrenergic receptor; calcium chloride; n (g) nitroarginine methyl ester; naloxone; plant extract; propranolol; unclassified drug; voltage gated calcium channel, Allium; Allium ampeloprasum; animal experiment; animal tissue; article; controlled study; dose response; drug effect; gastrointestinal disease; ileum contraction; male; nonhuman; rat
Subjects: WI Digestive System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 02 Aug 2017 08:49
Last Modified: 11 Jun 2018 08:13

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