Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: An additional mechanism for the hypolipidemic effects of berberine

Heidarian, E. and Rafieian-Kopaei, M. and Khoshdel, A. and Bakhshesh, M. (2014) Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: An additional mechanism for the hypolipidemic effects of berberine. Asian Pacific Journal of Tropical Biomedicine, 4. S429-S435.

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Abstract

Objective: To evaluate the effects of berberine (BBR) on the liver phosphatidate phosphohydrolase (PAP) and plasma lipids in rats fed on high lipogenic and normal diet. Methods: Forty rats were randomly divided into 5 groups. Group I (control) received standard diet. Group II received standard diet plus 90 mg/kg BBR and Groups IV received lipogenic diet (containing sunflower oil, cholesterol and ethanol) without treatment. Groups III and V received lipogenic diet plus 90 mg/kg BBR and 30 mg/kg gemfibrozil, respectively. On Day 60 of the experiment, blood samples were collected and PAP, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, very low density lipoprotein, malondialdehyde, plasma antioxidant, and liver histopathology assessments were conducted. Results: PAP, plasma triglyceride, total cholesterol, very low density lipoprotein, and malondialdehyde levels decreased significantly (P < 0.05) in Group III compared to Group IV (24 94, 36 11, 21 18, 36.86 and 19 59, respectively). The liver triglyceride and cholesterol in Groups III and V had a remarkable decrease (P < 0.001) compared with Group IV (24.94 and 49.13, respectively). There was a significant reduction (P < 0.05) in atherogenic index in Groups III compared with Group IV. Conclusions: These results clearly suggested that BBR could be effective in reducing liver PAP, lipid abnormality, liver triglyceride and lateral side effects of hyperlipidemia. © 2014 by the Asian Pacific Journal of Tropical Biomedicine.

Item Type: Article
Additional Information: cited By 12
Uncontrolled Keywords: alcohol; berberine; cholesterol; gemfibrozil; lipid; malonaldehyde; phosphatidate phosphatase; sunflower oil; triacylglycerol; very low density lipoprotein, animal experiment; animal model; animal tissue; Article; atherogenesis; blood sampling; cholesterol blood level; controlled study; drug activity; drug effect; hyperlipidemia; hypolipidemic effect; lipid blood level; lipid diet; lipid liver level; male; metabolism; nonhuman; randomization; rat, Helianthus; Rattus
Subjects: WK Endocrine System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 02 Aug 2017 06:53
Last Modified: 02 Aug 2017 06:53
URI: http://eprints.skums.ac.ir/id/eprint/2244

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