The effects of hydro-alcoholic extract of celery on lipid profile of rats fed a high fat diet

Kooti, Wesam. and Ghasemiboroon, Maryam. and Asadi-Samani, Majid. and Ahangarpoor, Akram. and Noori Ahmad Abadi, Mosayeb. and Afrisham, Reza. and Dashti, Nader. (2014) The effects of hydro-alcoholic extract of celery on lipid profile of rats fed a high fat diet. Advances in Environmental Biology, 8 (9 SPEC). pp. 325-330.

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Abstract

Background and Objectives: Decrease in serum lipids by dietary or pharmacological intervention prevents progression of atherosclerosis and cardiovascular diseases. The aim of this study was to investigate the effects of hydro-alcoholic extract of celery (Apium graveolens) on lipid profile of rats fed a high fat diet. Materials and Methods: In this experimental study, 24 Wistar rats were randomly allocated into four groups. The control group received saline with high-fat diet and treatment groups did hydroalcoholic extract at doses of 100 and 200 mg/kg/BW with high fat diet by gavage over a 30-day period. Afterwards, the serum levels of lipids (triglyceride, cholesterol, LDL, HDL, and VLDL) were determined. The data were analyzed by one-way ANOVA test using SPSS15 software. Results: Hydro-alcoholic extract of celery significantly decreased cholesterol and LDL in treatment groups compared with control group (P≤0.05); but had no significant effects in serum levels of triglyceride, HDL, and VLDL (P>0.05). Conclusions: Probably celery consumption due to the antioxidant properties leads to appropriate changes in serum lipid profiles and reduces them. Therefore it could be useful in the treatment of hyperlipidemia. © 2014 AENSI Publisher All rights reserved.

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