Association of deficiency of coagulation factors (Prs, Prc, ATIII) and FVL positivity with preeclampsia and/or eclampsia in pregnant women

Al-e-Rasul Dehkordi, Maryam. and Soleimani, Akbar. and Haji-Gholami, Ali. and Kazemi Vardanjani, Abdolrahim. and Al-e-Rasul Dehkordi, Saeid. (2014) Association of deficiency of coagulation factors (Prs, Prc, ATIII) and FVL positivity with preeclampsia and/or eclampsia in pregnant women. International Journal of Hematology-Oncology and Stem Cell Research, 8 (4). pp. 5-11.


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Background: Thrombophilia is a pathological state of increased blood coagulability. It causes problems during pregnancy including preeclampsia, stillbirth, repeated abortions, and detached pair. Out of the most prevalent factors causing inherited thrombophilia, protein S (Prs), protein C (Prc), and antithrombin III (ATIII) deficiency, and Factor V Leiden (FVL) mutation could be mentioned. This study aimed to investigate association of these parameters with preeclampsia. Methods: In this case-control study, 142 pregnant women with preeclampsia referred to Obstetric Clinic of Hajar Hospital, southwest of Iran, were assigned to the case group after clinical laboratory tests and according to specialist point of view and 142 pregnant women with normal blood pressure were assigned to the control group. After obtaining consent and completing relevant questionnaire, a 4-cc blood sample was taken from the patients. Coagulation factors and FVL rate were measured and after 6 months patients were followed- up. Data analysis was done by SPSS software using t-test. Results: In view of deficiency of Prs, Prc, and ATIII, no statistically significant association was observed between case and control groups (P>0.05). Statistical t-test indicated that the rate of FVL deficiency in pregnant patients with preeclampsia was significantly different from that in the control group (p=0.03). In addition, the body mass index of case group was significantly higher than that of control group prior to pregnancy (P=0.001). In case group, preeclampsia history contributed to development of current preeclampsia in contrast to control group (p<0.001). The patients of case group were followed up after 6 months in view of blood pressure and all had a normal mean blood pressure at the completion of the study. Conclusion: Measurement of FVL deficiency could help to decrease the unpleasant complications of vascular disorders during pregnancy. But, screening test for pre-eclampsia does not seem necessary to determine the deficiency of coagulation factors, Prs, Prc, and ATIII. © 2014, Tehran University of Medical Sciences (TUMS). All rights reserved.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: antithrombin III; blood clotting factor 5 Leiden; protein C; protein S, adult; antithrombin III deficiency; Article; blood pressure; blood sampling; body mass; case control study; controlled study; disease association; eclampsia; female; follow up; gene mutation; human; Iran; major clinical study; maternal serum screening test; preeclampsia; pregnant woman; protein C deficiency; protein determination; protein S deficiency; thrombophilia
Subjects: WH Hemic and Lymphatic System
WQ Obstetrics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Reserach Vice-Chancellar Department
Depositing User: Users 1 not found.
Date Deposited: 02 Aug 2017 03:49
Last Modified: 08 May 2018 07:37

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