A study of the effect of prostodin and hydroalcoholic extract of Malva neglecta on kidney histopathology and renal factors in female rats

Beyrami-Miavagi, Amineh. and Farokhi, Farah. and Asadi-Samani, Majid. (2014) A study of the effect of prostodin and hydroalcoholic extract of Malva neglecta on kidney histopathology and renal factors in female rats. Advances in Environmental Biology, 8 (9 SPEC). pp. 942-947.


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Background: Prostodin is often used to terminate the pregnancy, but frequently it causes free radicals development in and oxidative damages to the body tissues including kidneys. Malva neglecta with antioxidant and contraceptive properties could be an appropriate alternative to synthetic drugs. This study was designed and conducted to compare the side effects of M. neglecta hydroalcoholic extract with those of prostodin on kidney tissue of rats. Methods: In this experimental study, 24 rats were assigned into four groups of six each; the group 1 as control received water and normal food. The groups 2 and 3 received oral M. neglecta hydroalcoholic extract at respectively 200 and 500 mg/kg/day and the group 4 was intrapertoneally injected with prostodin at 2 mg/kg/day. After 18 days of treatment, the rats were anesthetized, and after the blood was taken for biochemical experiments, their kidneys were isolated and studied using optical microscope after the tissue fragments were prepared and stained with hematoxylin and eosin. Results: Creatinine and urea levels decreased significantly in the groups treated with M. neglecta extract and increased significantly in the group receiving prostodin (p<0.05). In histopathologic studies, glomerular hypertrophy was observed in the rats treated with prostodin. In the groups receiving M. neglecta glomeruli structure was normal, while tubular damage was seen in some tubes. Conclusions: Prostodin caused severe damages to the kidneys through developing glomerular hypertrophy, decreasing urinary space, and increasing creatinine and urea of blood serum, but M. neglecta extract developed no adverse changes in glomeruli form and general structure of the kidney compared with the control group; therefore, M. neglecta could be a suitable alternative to prostodin thanks to its contraceptive property and fewer side effects. © 2014 AENSI Publisher All rights reserved.

Item Type: Article
Additional Information: cited By 27
Uncontrolled Keywords: Malva neglecta, Prostodin, Kidney, Female rat
Subjects: WJ Urogenital System
QZ pathology-Neoplasms
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 01 Aug 2017 09:27
Last Modified: 04 Feb 2018 07:02
URI: http://eprints.skums.ac.ir/id/eprint/2209

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