Hepatoprotective action of echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats

Heidarian, Esfandiar. and Saffari, Javad. and Jafari-Dehkordi, Effat. (2014) Hepatoprotective action of echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats. Journal of Dietary Supplements, 11 (1). pp. 53-63.

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Context: Acetaminophen, an analgesic and antipyretic drug, causes fulminant hepatic injury at high doses. Objective: This study evaluated the effects of Echinophora platyloba extract on acetaminophen-induced hepatotoxicity in rats. Materials and methods: Forty-eight rats were divided into six groups. The first (control) and second (test without treatment) groups were administered the solvent of the drug in the morning (08:00) and evening (16:00) on days 1 and 2 but, the third, fourth, and fifth groups received 200, 500, and 1,000 mg/kg b.w E. platyloba extract by gavage on the same days, respectively. The sixth group (positive control) received 200 mg/kg b.w silymarin. Then all groups, except the control group, received 400 mg/kg acetaminophen by gavage on day 2 (10:00). After 24 hr, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde (MDA), and antioxidant capacity plus liver catalase (CAT) activity and histopathological studies were determined. Data were analyzed with one-way analysis of variance (ANOVA). Results: Treatment of rats with different doses of E. platyloba extract significantly reduced (p < .05) the elevated serum levels of ALT, AST, ALP, and MDA compared to the untreated group. The effects of 1,000 mg/kg E. platyloba were similar to the control and treated silymarin groups. Moreover, E. platyloba significantly increased the activity of liver CAT and serum antioxidant capacity at different doses. Also, E. platyloba extract improved liver histopathological changes compared with the respective control group. Conclusion: The results suggest that E. platyloba extract has impressive hepatoprotective effects on acute acetaminophen-induced liver injuries. © 2014 Informa Healthcare USA, Inc.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: alanine aminotransferase; alkaline phosphatase; antioxidant; aspartate aminotransferase; catalase; malonaldehyde; paracetamol; plant extract, analysis of variance; animal; Apiaceae; article; blood; drug effect; enzymology; liver; metabolism; phytotherapy; plant leaf; rat; toxic hepatitis, Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Animals; Antioxidants; Apiaceae; Aspartate Aminotransferases; Catalase; Drug-Induced Liver Injury; Liver; Malondialdehyde; Phytotherapy; Plant Extracts; Plant Leaves; Rats
Subjects: WK Endocrine System
QV pharmacology > QV 600 Toxicology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 01 Aug 2017 04:07
Last Modified: 03 Mar 2018 07:06
URI: http://eprints.skums.ac.ir/id/eprint/2156

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