Antioxidant activity and preventive effect of aqueous leaf extract of Aloe Vera on gentamicin-induced nephrotoxicity in male Wistar rats

Baradaran, A. and Nasri, H. and Nematbakhsh, M. and Rafieian-Kopaei, M. (2014) Antioxidant activity and preventive effect of aqueous leaf extract of Aloe Vera on gentamicin-induced nephrotoxicity in male Wistar rats. Clinica Terapeutica, 165 (1). pp. 7-11.

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Abstract

Objective(s): In the present study, the nephroprotective and curative effects of aqueous extract of AV on gentamicin-induced tubular toxicity in male Wistar rats were investigated. Antioxidant activity, phenolic and flavonoid contents of AV were also determined. Materials and Methods: In a preclinical study, 60 male Wistar rats were designated into 6 groups of 10 and treated as follows: Group I: Treated with vehicle (distilled water) and kept as control. Group II: Received 300 mg/kg/d AV for three days then, AV plus GM (80 mg/kg; intraperitoneally) for 7 more days and sacrificed. Group III: Received 300 mg/kg AV orally for 10 days, then sacrificed. Group IV: Received GM for 7 days and sacrificed. Group V: Received GM for 7 days and saline for ten days and sacrificed on 17th day. Group VI: Received GM for 7 days, then AV for 10 days and sacrificed. Results: The levels of flavonoid and phenolic compounds in Aloe vera extract were 43±3.8 mg/g (Rutin equivalent) and 80.1±3.8 mg/g (Gallic acid equivalent), respectively. The antioxidant activity of the extract was 38. The intensity of nephrotoxicity in group 2 that received AV 300 mg/kg/d as prophylaxis was not significantly different from the group I and from the group II which treated with 300 mg/kg/d AV without GM. This finding reveals that AV as prophylaxis could potentially attenuate the GM-induced nephrotoxicity. Conclusion: Aole vera significantly protects the renal cells and reduces the severity of tubular damage caused by gentamicin. However, it cannot regenerate tubular damage. © Societá Editrice Universo (SEU).

Item Type: Article
Additional Information: cited By 96
Uncontrolled Keywords: antioxidant; gentamicin; plant extract, Aloe; animal; chemistry; drug effects; kidney; male; oxidation reduction reaction; pathology; rat; Wistar rat, Aloe; Animals; Antioxidants; Gentamicins; Kidney; Male; Oxidation-Reduction; Plant Extracts; Rats; Rats, Wistar
Subjects: WJ Urogenital System
QV pharmacology > QV 704 Pharmaceutics
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 01 Aug 2017 04:01
Last Modified: 01 Aug 2017 04:01
URI: http://eprints.skums.ac.ir/id/eprint/2153

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