A comparison of the efficacy of amoxicillin and nasal irrigation in treatment of acute sinusitis in children

Khoshdel, Abolfazl. and Panahandeh, Gholamreza. and Noorbakhsh, Mohamad Kazem. and Malek Ahmadi, Mohamad Reza. and Lotfizadeh Dehkordi, Masoud. and Parvin, Neda. (2014) A comparison of the efficacy of amoxicillin and nasal irrigation in treatment of acute sinusitis in children. Korean Journal of Pediatrics, 57 (11). pp. 479-483.


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Purpose: The efficacy of antibiotic therapy for acute sinusitis is controversial. This study aimed to compare the efficacies of amoxicillin with nasal irrigation and nasal irrigation alone for acute sinusitis in children. Methods: This randomized, double-blind, controlled study included 80 children aged 4–15 years with a clinical presentation of acute sinusitis. Patients were randomly assigned to receive either amoxicillin (80 mg/kg/day) in 3 divided doses orally for 14 days with saline nasal irrigation (for 5 days) and 0.25 phenylephrine (for 2 days) or the same treatment without amoxicillin. Clinical improvements in their initial symptoms were assessed on days 3, 14, 21, and 28. Results: On day 3, patients in the amoxicillin with nasal irrigation group showed significant clinical improvement (P =0.001), but there was no significant difference in the degree of improvement between the amoxicillin with nasal irrigation and nasal irrigation alone groups during follow-up (P >0.05). In addition, no significant differences were seen in age, sex, and degree of improvement between groups (P > 0.05). Conclusion: High-dose amoxicillin with saline nasal irrigation relieved acute sinusitis symptoms faster and more often than saline nasal irrigation alone. However, antibiotic treatment for acute sinusitis confers only a small therapeutic benefit over nasal irrigation. © 2014 by The Korean Pediatric Society.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: amoxicillin; phenylephrine, acute sinusitis; adolescent; Article; bacterial sinusitis; breathing; child; clinical assessment; clinical effectiveness; comparative effectiveness; controlled study; double blind procedure; face tenderness; female; follow up; head and neck disease; human; jaw pain; major clinical study; male; nasal lavage; nose secretion; patient compliance; randomized controlled trial; symptom assessment; treatment outcome
Subjects: WS Pediatrics
QV pharmacology > QV 704 Pharmaceutics
WV Otolaryngology
Divisions: Faculty of Health
Faculty of Medicine
Faculty of Nursing and Midwifery
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: zahra bagheri .
Date Deposited: 01 Aug 2017 03:25
Last Modified: 15 Apr 2018 03:45
URI: http://eprints.skums.ac.ir/id/eprint/2140

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