The radioprotective effect of resveratrol against genotoxicity induced by γ-irradiation in mice blood lymphocytes

Koohian, F. and Shanei, A. and Shahbazi-Gahrouei, D. and Hejazi, S.H. and Moradi, M.-T. (2017) The radioprotective effect of resveratrol against genotoxicity induced by γ-irradiation in mice blood lymphocytes. Dose-Response, 15 (2).

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Abstract

In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4'-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body γ-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated. The results of the alkaline comet assay showed that RSV significantly inhibited radiationinduced DNA damage. We observed that RSV protects blood lymphocyte against radiation-induced damage in mice.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Comet assay ,Lymphocyte ,Radiation, Radioprotective Resveratrol
Subjects: WN Radiology . Diagnostic Imaging
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 19 Jun 2017 06:38
Last Modified: 19 Jun 2017 07:53
URI: http://eprints.skums.ac.ir/id/eprint/212

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