Lack of Association between ESR1 and CYP1A1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent

Taghizade Mortezaee, Fatemeh. and Tabatabaiefar, Mohammad Amin. and Hashemzadeh-Chaleshtori, Morteza. and Miraj, Sepide. (2014) Lack of Association between ESR1 and CYP1A1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent. CELL JOURNAL, 16 (2). pp. 225-230.

[img]
Preview
Text
13.pdf

Download (510kB) | Preview

Abstract

Uterine leiomyonna (UL) is the most common benign smooth muscle cell tumor with as yet unknown etiology and pathogenesis. This study was carried out to investigate the association of ESR1-351 A>G, ESR1 -397 T>C and CYP1A1 (IIe462Val) polymorphisms with UL in female patients of Iranian origin. In this case-control study, 276 patients with UL and 156 healthy women were recruited. The genetic polymorphisms ESR1-351 A>G, ESR1-397 T>C and CYP1A1 (IIe462Val) were genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). No significant difference were found in frequencies of both genotypes and alleles of ESR1-351 A>G, ESR1-397 T>C and CYP1A1 (IIe462Val) polymorphisms between the two groups (p>0.05). Our findings indicated that these ESR1 and CYP1A1 polymorphisms were not associated with the development of UL in the cases reported here.

Item Type: Article
Uncontrolled Keywords: ESR1; CYP1A1; Uterine Leiomyoma; Polymorphism
Subjects: WP Gynecology
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 31 Jul 2017 04:07
Last Modified: 16 May 2018 05:06
URI: http://eprints.skums.ac.ir/id/eprint/2095

Actions (login required)

View Item View Item