Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis

Shaygannejad, Vahid. and Montazeri, Saeed. and Jamshidian, Azam. and Tahani, Soheil. and Gharagozloo, Marjan. and Ashtari, Fereshteh. and Vesal, Sahar. and Hasheminia, Seyed Javad. and Dehghani, Leila. (2014) Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis. IRANIAN JOURNAL OF IMMUNOLOGY, 11 (2). pp. 134-138.

[img]
Preview
Text
12.pdf

Download (236kB) | Preview

Abstract

Background: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration. Objective: To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients. Methods: We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and anti-inflammatory ones (IL-10 and TGF-beta) in multiple sclerosis (MS) patients. The serum concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects. Results: Our data showed that the MK concentration in MS patients is lower than healthy controls (341.15 +/- 40.71 Pg/ml vs. 620.15 +/- 98.61 Pg/ml, respectively, p= 0.015). We also observed a significant decrease in IL-10, IL-23, and TGF-beta cytokine levels in MS patients. There was a significant correlation between MK and IL-23 concentrations in our study (r = + 0.829, p <= 0.001). Conclusion: These results confirm a role for MK in inflammatory reactions in MS.

Item Type: Article
Uncontrolled Keywords: IL-10; IL-17; IL-23; Midkine; Multiple Sclerosis; TGF-beta
Subjects: WL Nervous system
QU Biochemistry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Microbiology
Depositing User: zahra bagheri .
Date Deposited: 31 Jul 2017 04:04
Last Modified: 24 Feb 2018 06:34
URI: http://eprints.skums.ac.ir/id/eprint/2094

Actions (login required)

View Item View Item