Pulmonary function tests in ulcerative colitis

Amra, Babak. and Ataabadi, Ghazal. and Emami, Mohamad Hassan. and Hassanzadeh, Akbar. and Golshan, Mohammad. and Soltaninejad, Forough. (2014) Pulmonary function tests in ulcerative colitis. JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 19 (7). pp. 605-609.


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Background: Pulmonary impairment in patients suffering ulcerative colitis (UC) has been suggested by several investigators using standard pulmonary function tests (PFTs). This changes in pulmonary function associated with minimal respiratory symptoms have been documented, especially in patients with active disease. The aim of this prospective study was to determine airway resistance and lung volumes in patients with UC who have no respiratory symptoms in comparisons to a healthy control group. Materials and Methods: We evaluated a total of 30 patients with UC by means of spirometry, body plethysmography, and impulse oscillometry. The patients were not complaining of any pulmonary symptoms and did not present any history of previous respiratory diseases. As controls we examined 30 healthy subjects matched for gender, age, and smoking status. The relationship between PFT, lung volume, and airway resistance; and the activity, localization, and duration of the UC disease were analyzed. Results: There was a significant difference between airway resistances (kPa/L/s) measured by body plethysmography in patients with UC and those of the controls (R5hz; 0.60 +/- 0.44 vs. 0.39 +/- 0.13; P < 0.001) and R20hz (0.37 +/- 0.19 vs. 0.29 +/- 0.1, P = 0.02). There were no correlation between PFT, airway resistance and site and scoring activity (P > 0.05). Conclusion: Despite the lack of pulmonary symptoms, increased airway resistance was found in UC patients. We also have not found correlation between PFT, lung volume and airway resistance values and scoring of UC activity.

Item Type: Article
Uncontrolled Keywords: Body plethysmography; impulse oscillometry; ulcerative colitis
Subjects: WF Respiratory System
WI Digestive System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: Users 1 not found.
Date Deposited: 31 Jul 2017 03:29
Last Modified: 02 Jun 2018 04:24
URI: http://eprints.skums.ac.ir/id/eprint/2084

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