Anethum graveolens and hyperlipidemia: A randomized clinical trial

Mirhosseini, M. and Baradaran, A. and Rafieian-Kopaei, M. (2014) Anethum graveolens and hyperlipidemia: A randomized clinical trial. JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 19 (8). pp. 758-761.

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Abstract

Background: It has been established that hyperlipidemia increases the incidence and mortality associated with coronary heart disease. In this study, the effects of Dill (Anethum graveolens) were evaluated on lipid profile of hypercholesterolemic patients. Materials and Methods: In this clinical study, 91 hyperlipidemic patients were randomly designated into two groups. One group received gemfibrozil (900 mg daily) and the other group received Dill tablet (six tablets daily) for 2 months. The blood lipids including total cholesterol, triglyceride and high density lipoprotein (HDL)-cholesterol from each group were assessed at the beginning and end of the trial. Results: Use of gemfibrozil brought about increased HDL-cholesterol by 3.91% (P < 0.05) and reduced triglyceride and total cholesterol by 32.7% (P < 0.05) and 9.41% (P < 0.05), respectively. Applying Dill tablet for 2 months resulted in reduction of total cholesterol up to 18% (P < 0.05) and triglyceride by 7.38% (P < 0.05). However, circulating HDL-cholesterol was not affected by this treatment. In this study, gemfibrozil decreased triglyceride and increased HDL-cholesterol more than anethum (P < 0.05). Anethum decreased total cholesterol more than gemfibrozil (P < 0.05). Patients treated with anethum did not report any side effects. Conclusion: The results of this trial indicate that Dill might be beneficial for hypercholesterolemic and hypertriglycemic patients.

Item Type: Article
Uncontrolled Keywords: Anethum graveolens; gemfibrozil; high density lipoprotein; cholesterol; total cholesterol; triglyceride
Subjects: QU Biochemistry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 30 Jul 2017 09:59
Last Modified: 30 Jul 2017 09:59
URI: http://eprints.skums.ac.ir/id/eprint/2078

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