Prevalence of hypertension and type 2 diabetes mellitus in patients with colorectal cancer and their median survival time: A cohort study

Ahmadi, A. and Mobasheri, M. and Hashemi-Nazari, S.S. and Baradaran, A. and Molavi Choobini, Z. (2014) Prevalence of hypertension and type 2 diabetes mellitus in patients with colorectal cancer and their median survival time: A cohort study. JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 19 (9). pp. 850-854.

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Abstract

Background: Type 2 diabetes mellitus (DM) and hypertension are worldwide epidemic. Association between DM and colon cancer was obtained in previous studies. Prevalence of DM and hypertension in the patients with colorectal cancer (CRC) has not been reported in Iran. The present study was aimed to investigate the prevalence of hypertension and type 2 DM and their effect on median survival time in patients with CRC. Materials and Methods: Overall, 2570 individual-year follow-ups were conducted for 1127 patients with CRC. For the diagnosis of type 2 DM, fasting blood sugar test and glycosylated hemoglobin test were used and for hypertension, blood pressure was measured in two turns. The descriptive indices were calculated, and the mean and median survival from CRC diagnosis time was calculated using survival analysis and a comparison among survival times was done through log-rank test. Stata software 12 (Stata Corp. 2011. Stata Statistical Software: Release 12. College Station, TX: Stata Corp LP) was used for data analysis. Results: The prevalence of hypertension and type 2 DM in the patients with CRC was respectively 13.38% (95% confidence interval CI]: 11.1-15.8) and 8.69% (95% CI: 7-10.7). Median survival time in patients with hypertension and DM were 8.52 and 4.9 years. According to log-rank test, no significant difference was observed between the survival time of CRC patients suffering from hypertension and diabetes type 2. Conclusion: The obtained findings in this study indicate that survival time in patients with type 2 DM less than hypertension but two metabolic diseases have the same effect on survival rate of the patients with CRC. Understanding the risk factors for CRC may guide the development of strategies targeted toward its prevention.

Item Type: Article
Uncontrolled Keywords: Colorectal cancer; diabetes; hypertension; survival time
Subjects: WD Nutrition Disease and metabolic diseases
WG Cardiovascular System
WI Digestive System
Divisions: Faculty of Health > Department of Epidemiology
Faculty of Health > Department of Public Health
Depositing User: zahra bagheri .
Date Deposited: 30 Jul 2017 09:13
Last Modified: 30 Jul 2017 09:13
URI: http://eprints.skums.ac.ir/id/eprint/2072

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