Association between interleukin-10-1082 G/A and tumor necrosis factor-α 308 G/A gene polymorphisms and respiratory distress syndrome in Iranian preterm infants

Khoshdel, A. and Kheiri, S. and Omidvari, P. and Moradi, F. and Hamidi, M. and Teimori, H. (2017) Association between interleukin-10-1082 G/A and tumor necrosis factor-α 308 G/A gene polymorphisms and respiratory distress syndrome in Iranian preterm infants. Mediators of Inflammation, 2017.

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Abstract

Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively. One-hundred and nineteen out of 238 infants had RDS (50%). The age of the mothers and gestational age ranged 17-45 (mean: 28.6±5.3) years and 24-34 (mean: 34.3±2.38) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. TNF-a-308 G/G was not found in both groups. Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively. IL-10-1082 A/A was not found in both groups. The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (P<0.05). We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082. © 2017 Abolfazl Khoshdel et al.

Item Type: Article
Additional Information: cited By 0
Subjects: WS Pediatrics
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Pediatrics
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: zahra bagheri .
Date Deposited: 18 Jun 2017 08:17
Last Modified: 19 Jun 2017 09:01
URI: http://eprints.skums.ac.ir/id/eprint/207

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