Effects of synbiotics on treatment of children with failure to thrive: A triple blind placebo-controlled trial

Famouri, Fatemeh. and Khoshdel, Abolfazl. and Golshani, Arghavan. and Kheiri, Soleiman. and Saneian, Hossein. and Kelishadi, Roya. (2014) Effects of synbiotics on treatment of children with failure to thrive: A triple blind placebo-controlled trial. JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 19 (11). pp. 1046-1050.


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Background: Failure to thrive (FTT) is a common problem of children especially in underdeveloped countries. In addition to its short-term adverse health effects, it is associated with long-term behavioral and cognitive defects. One of the recommended treatment modalities for FTT is using synbiotics. Due to high prevalence of FTT with undefined organic causes and failure of most medications on treatment of this type of FTT, we decided to search the effect of synbiotics on these patients. Materials and Methods: A randomized, triple-blinded, placebo-controlled trial study was done from 2011 to 2012. A number of 84 patients were randomly assigned to intervention and control groups. The synbiotics sachets were administered to study group for 6 months. The growth indices were measured at the beginning of the trial after 3 and 6 months, and compared with control. Results: Variance analysis of observations showed improvement of growth indices in both groups. The increase in weight was significantly higher in synbiotics group than in controls (P < 0.05). The corresponding figure was not significant for height and head circumference (P > 0.05). At the beginning of the trial, the mean weights were 10.25 +/- 0.20 kg and 10.750 +/- 0.160 kg in intervention and control groups, respectively, Meanwhile, after 6 months, the mean weights of two groups became 12.280 +/- 0.190 and 11.760 +/- 0.17 kg in intervention and control groups, respectively. This result has confirmed that the effect of synbiotics is significant on weight gain of our patients. Conclusion: Our findings support beneficial effects of synbiotics in weight gain of children with FTT.

Item Type: Article
Uncontrolled Keywords: Children; failure to thrive; growth; synbiotics
Subjects: WK Endocrine System
WS Pediatrics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Pediatrics
Depositing User: Users 1 not found.
Date Deposited: 30 Jul 2017 05:58
Last Modified: 23 May 2018 10:25
URI: http://eprints.skums.ac.ir/id/eprint/2048

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