Interleukin-1 β gene polymorphisms in Iranian patients with uterine fibroid, a case-control study

Taghizade Mortezaee, Fatemeh. and Hashemzadeh-Chaleshtori, Morteza. and Kheiri, Soleiman. and Farrokhi, Effat. and Shariati, Laleh. and Tabatabaiefar, Mohammad Amin. and Miraj, Sepide. (2015) Interleukin-1 β gene polymorphisms in Iranian patients with uterine fibroid, a case-control study. Biosciences Biotechnology Research Asia, 12 (1). pp. 341-345.


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Uterine leiomyoma (UL) or fibroid is the most common estrogen- dependent tumor of the reproductive system. Almost a quarter of women at reproductive age are affected with this benign tumor. The purpose of the present study was to investigate the possible association of IL-1β-511and IL-1β 3954 polymorphisms with UL in the women of Charmahal & Bakhtiari province of Iran. Totally, 276 patients with UL and 157 healthy control women were studied. The genetic polymorphisms for IL-1β-511and IL-1β 3954 were analyzed by PCR-RFLP method. The results were analyzed with SPSS software using χ2 test. The TC genotypes of the IL-1β -511C/T polymorphism showed a decreased risk of UL (OR = 0.232, P = 0.01, 95 % CI = 0.11 - 0.48). A significant difference was found for the C allele frequencies of the IL-1 β -511 C>T polymorphism between the two groups (OR = 0.232, P = 0.01, 95% CI = 0.11 - 0.48). However, no significant difference was found for the IL-1 â -3954 polymorphism between the two groups. Our findings indicated that IL-1 â -511C>T promoter polymorphism affects the risk of UL in the women of our study and this polymorphism might be involved in the pathogens of this disease.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: interleukin 1alpha; interleukin 1beta, adult; Article; case control study; controlled study; DNA sequence; exon; female; gene frequency; genetic association; genetic risk; genotype; human; hysterectomy; Iranian (citizen); polymerase chain reaction; promoter region; restriction fragment length polymorphism; single nucleotide polymorphism; uterus myoma
Subjects: WP Gynecology
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: Users 1 not found.
Date Deposited: 30 Jul 2017 03:15
Last Modified: 16 May 2018 05:03

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