Effect of glycyrrhetinic acid and glycyrrhizic acid on the expression of CXCR4 in epithelial cells of gastric carcinoma

Mehdinejadiani, Kobra. and Jalili, Ali. and Rafieian-Kopaei, Mahmoud. and Salimzadeh, Loghman. and Mehdinejadiani, Shayesteh. and Mousavi, Seyed Mohammad javad. and shirzad, Hedayatollah. (2015) Effect of glycyrrhetinic acid and glycyrrhizic acid on the expression of CXCR4 in epithelial cells of gastric carcinoma. Journal of Mazandaran University of Medical Sciences, 25 (123). pp. 152-161.

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Abstract

Background and purpose: Gastric cancer is one of the most common cancers and the second common cause of cancer death worldwide. Surgery is the only treatment for gastric cancer but about 50% percent of patients have inoperable tumors. For these patients, combined chemotherapy is the primary treatment which has some side effects. CXCR4 that is expressed on the surface of tumor cells plays a role in metastasis and chemotaxis of tumor cells to different tissues. Licorice compounds are known to have anticancer properties, so this study aimed at investigating their effects on the expression of CXCR4 receptor in gastric cancer AGS cells. Materials and methods: In this experimental study, 106 cells were poured in all wells of 6 pieces plates and exposed to various concentrations of Glycyrrhetinic acid and Glycyrrhizic acid for 24 hours. The CXCR4 gene expression levels were determined by Real−Time PCR and the level of expression in the groups was compared using ANOVA and Dunntt's post hoc test in prism software. P <0.05 was considered as statistically significant. Results: The results showed a significant decrease in CXCR4 gene expression in cells exposed to acid Glycyrrhizic and acid Glycyrrhetinic at 24 hours compared with that of the control group. In fact, decreased expressions of CXCR4 reduced the rates of metastasis and chemotaxis Conclusion: The compounds used in this study reduced the CXCR4 gene expression, so, they could be used as effective treatments for gastric cancer.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: chemokine receptor CXCR4; glycyrrhetinic acid; glycyrrhizic acid, Article; chemotaxis; controlled study; drug effect; epithelium cell; experimental study; gastric cancer cell line; gene expression regulation; human; human cell; metastasis; real time polymerase chain reaction; stomach carcinoma
Subjects: WI Digestive System
QZ pathology-Neoplasms
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 29 Jul 2017 09:42
Last Modified: 04 Mar 2018 04:58
URI: http://eprints.skums.ac.ir/id/eprint/2007

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