Effect of hydroalcoholic extract of Chevil (Ferulago angulata) on glucose and lipid in diabetic male rats

Musavi-Ezmareh, Seyedeh Fatemeh. and Mazani, Mohammad. and Heidarian, Esfandiar. and Alipanah-Moghadam, Reza. and Rafieian-Kopaei, Mahmoud. and Ebrahimi, Marzieh. and Shahinfard, Najmeh. and Ghezel-Sofli, Eslam. (2015) Effect of hydroalcoholic extract of Chevil (Ferulago angulata) on glucose and lipid in diabetic male rats. Iranian Journal of Endocrinology and Metabolism, 17 (3). pp. 230-237.

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Abstract

Introduction: Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male rats. Materials and Methods: In this study, 54 male Wistar rats weighing 200-250 g were divided into 6 groups (n=9 each) and studied for 4 weeks. The groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and 800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats treated with 150 mg/kg body weight of metformin. At the end of study, FBS, Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were analyzed by one-way ANOVA. Results: Findings showed a significant reduction (P<0.05) of FBS in all groups with three doses of the extract, 26%, 59.3%, 69.4% respectively), Triglycerides (at 200 and 400 mg/kg of the extract respectively 16.1% and 34.1%), Cholesterol (800 mg/kg of the extract, 20.9%), LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively and a significant increase (P<0.05) in HDL-C in all three doses of the extract, 32.6%, 36.4% and 37.1% respectively compared to the control group was observed in diabetic rats treated with Chevil. Conclusion: The results of this study showed that Chevil extract reduces blood sugar and improves blood lipid profiles in diabetic rats.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Ferulago angulata extract; high density lipoprotein cholesterol; low density lipoprotein cholesterol; metformin; plant extract; triacylglycerol; unclassified drug, animal experiment; animal model; Apiaceae; Article; cholesterol blood level; controlled study; diabetes mellitus; Ferulago angulata; glucose blood level; male; nonhuman; rat
Subjects: WD Nutrition Disease and metabolic diseases
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 29 Jul 2017 09:26
Last Modified: 11 Jun 2018 04:32
URI: http://eprints.skums.ac.ir/id/eprint/2000

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