Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: Involvement of oxytocinergic system

Amini-Khoei, H. and Amiri, S. and Mohammadi-Asl, A. and Alijanpour, S. and Poursaman, S. and Haj-Mirzaian, A. and Rastegar, M. and Mesdaghinia, A. and Banafshe, H.R. and Sadeghi, E. and Samiei, E. and Mehr, S.E. and Dehpour, A.R. (2017) Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: Involvement of oxytocinergic system. Neuropeptides, 61. pp. 77-85.

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Abstract

Early-life stress adversely affects the development of the brain, and alters a variety of behaviors such as pain in later life. In present study, we investigated how early-life stress (maternal separation or MS) can affect the nociceptive response later in life. We particularly focused on the role of oxytocin (OT) in regulating nociception in previously exposed (MS during early postnatal development) mice that were subjected to acute stress (restraint stress or RS). Further, we evaluated whether such modulation of pain sensation in MS mice are regulated by shared mechanisms of the OTergic and opioidergic systems. To do this, we assessed the underlying systems mediating the nociceptive response by administrating different antagonists (for both opioid and OTergic systems) under the different experimental conditions (control vs MS, and control plus RS vs MS plus RS). Our results showed that MS increased pain sensitivity in both tail-flick and hot-plate tests while after administration of OT (1 μg/μl/mouse, i.c.v) pain threshold was increased. Atosiban, an OT antagonist (10 μg/μl/mouse, i.c.v) abolished the effects of OT. While acute RS increased the pain threshold in control (and not MS) mice, treating MS mice with OT normalized the pain response to RS. This latter effect was reversed by atosiban and/or naltrexone, an opioid antagonist (0.5 μg/μl/mouse, i.c.v) suggesting that OT enhances the effect of endogenous opioids. OTergic system is involved in mediating the nociception under acute stress in mice subjected to early-life stress and OTergic and opioidergic systems interact to modulate pain sensitivity in MS mice

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Acute restraint stress, Maternal separation, Opioid ,Oxytocin, Pain threshold
Subjects: WM Psychiatry
QU Biochemistry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 20 Jun 2017 09:31
Last Modified: 20 Jun 2017 09:31
URI: http://eprints.skums.ac.ir/id/eprint/199

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