Inhibitory effect of Thymus vulgaris extract on memory impairment induced by scopolamine in rat

Rabiei, Zahra. and Mokhtari, Shiva. and Asgharzadeh, Samira. and Gholami-Arjenaki, Mostafa. and Rahnama, Samira. and Rafieian-Kopaei, Mahmoud. (2015) Inhibitory effect of Thymus vulgaris extract on memory impairment induced by scopolamine in rat. Asian Pacific Journal of Tropical Biomedicine, 5 (10). pp. 845-851.

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Abstract

Objective To investigate the effect of Thymus vulgaris (T. vulgaris) on learning and memory functions in scopolamine-induced memory deficit in rats. Memory enhancing activity in scopolamine-induced amnesic rats was investigated by assessing the Morris water maze and passive avoidance paradigm. Methods A total of 42 male Wistar rats were divided into 6 equal groups as follow: control group: received water, scopolamine treated group: received scopolamine 1 mg/kg for 15 days, two scopolamine + T. vulgaris treated groups: received scopolamine and T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days, two intact groups: received T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days. Results Administration of T. vulgaris extract significantly restored memory and learning impairments induced by scopolamine in the passive avoidance test and Morris water maze test. Conclusions T. vulgaris extract has repairing effects on memory and behavioral disorders produced by scopolamine and may have beneficial effects in the treatment of Alzheimer's disease.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: 1,1 diphenyl 2 picrylhydrazyl; flavonoid; flavonol; malonaldehyde; nitric oxide; phenol derivative; plant extract; scopolamine; Thymus vulgaris extract; unclassified drug; water, animal experiment; animal model; animal tissue; antioxidant activity; Article; brain; controlled study; drug activity; drug determination; drug tissue level; high performance liquid chromatography; IC50; learning; male; memory; memory disorder; memory enhancing activity; Morris water maze test; nonhuman; passive avoidance test; priority journal; rat; serum; treatment duration
Subjects: WM Psychiatry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 29 Jul 2017 06:29
Last Modified: 30 May 2018 04:11
URI: http://eprints.skums.ac.ir/id/eprint/1941

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