Effects of matricaria chamomilla extract on motor coordination impairment induced in rat and determination antioxidant properties of chamomile

Rabiei, Z. and Alibabaei, Z. and Rafieian-Kopaei, M. (2015) Effects of matricaria chamomilla extract on motor coordination impairment induced in rat and determination antioxidant properties of chamomile. Journal of Babol University of Medical Sciences, 17 (4). pp. 44-50.

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Abstract

Objective To evaluate the effect of ethanolic extract of chamomile on balance and motor learning in rats receiving scopolamine and intact rats. Methods Fourty-two rats were divided into 6 groups (n = 7). Control group received distilled water. Rats in Group 2 were given 1 mg/kg scopolamine. Groups 3 and 4 received chamomile extract 200 mg/kg and 500 mg/kg, respectively, and scopolamine simultaneously for 20 days. Intact groups (Groups 5 and 6) only received chamomile extract 200 mg/kg and 500 mg/kg, respectively. Motor coordination of rats was assessed with rotarod apparatus. Results According to the obtained results, compared with the control group, scopolamine significantly decreased time spent on rotarod performance (P < 0.001). Compared with scopolamine group, the strength and staying on rotarod apparatus in Group 3 significantly increased (P < 0.05). The results of this research showed that intact groups that received only chamomile extract at doses of 200 mg/kg and 500 mg/kg significantly increased time spent on rotarod, compared with scopolamine group (P < 0.001). Conclusions The results of this study indicated the high antioxidant property and protective effect of chamomile extract on motor coordination in the groups that received scopolamine.

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