Effects of matricaria chamomilla extract on motor coordination impairment induced in rat and determination antioxidant properties of chamomile

Rabiei, Z. and Alibabaei, Z. and Rafieian-Kopaei, M. (2015) Effects of matricaria chamomilla extract on motor coordination impairment induced in rat and determination antioxidant properties of chamomile. Journal of Babol University of Medical Sciences, 17 (4). pp. 44-50.

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Abstract

Objective To evaluate the effect of ethanolic extract of chamomile on balance and motor learning in rats receiving scopolamine and intact rats. Methods Fourty-two rats were divided into 6 groups (n = 7). Control group received distilled water. Rats in Group 2 were given 1 mg/kg scopolamine. Groups 3 and 4 received chamomile extract 200 mg/kg and 500 mg/kg, respectively, and scopolamine simultaneously for 20 days. Intact groups (Groups 5 and 6) only received chamomile extract 200 mg/kg and 500 mg/kg, respectively. Motor coordination of rats was assessed with rotarod apparatus. Results According to the obtained results, compared with the control group, scopolamine significantly decreased time spent on rotarod performance (P < 0.001). Compared with scopolamine group, the strength and staying on rotarod apparatus in Group 3 significantly increased (P < 0.05). The results of this research showed that intact groups that received only chamomile extract at doses of 200 mg/kg and 500 mg/kg significantly increased time spent on rotarod, compared with scopolamine group (P < 0.001). Conclusions The results of this study indicated the high antioxidant property and protective effect of chamomile extract on motor coordination in the groups that received scopolamine.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Matricaria chamomilla extract; scopolamine, Alzheimer disease; animal behavior; animal experiment; antioxidant activity; Article; controlled study; dementia; motor coordination; motor dysfunction; nonhuman; rat; rotarod test
Subjects: WB Practice of Medicine
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 29 Jul 2017 04:59
Last Modified: 29 Jul 2017 04:59
URI: http://eprints.skums.ac.ir/id/eprint/1900

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