MicroRNAs: effective elements in ear-related diseases and hearing loss

Mahmoudian-sani, M.-R. and Mehri-Ghahfarrokhi, A. and Ahmadinejad, F. and Hashemzadeh-Chaleshtori, M. and Saidijam, M. and Jami, M.-S. (2017) MicroRNAs: effective elements in ear-related diseases and hearing loss. European Archives of Oto-Rhino-Laryngology. pp. 1-8.

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Abstract

miRNAs are important factors for post-transcriptional process that controls gene expression at mRNA level. Various biological processes, including growth and differentiation, are regulated by miRNAs. miRNAs have been demonstrated to play an essential role in development and progression of hearing loss. Nowadays, miRNAs are known as critical factors involved in different physiological, biological, and pathological processes, such as gene expression, progressive sensorineural hearing loss, age-related hearing loss, noise-induced hearing loss, cholesteatoma, schwannomas, and inner ear inflammation. The miR-183 family (miR-183, miR-96 and miR-182) is expressed abundantly in some types of sensory cells in inner ear specially mechanosensory hair cells that exhibit a great expression level of this family. The plasma levels of miR-24-3p, miR-16-5p, miR-185-5p, and miR-451a were upregulated during noise exposures, and increased levels of miR-21 have been found in vestibular schwannomas and human cholesteatoma. In addition, upregulation of pro-apoptotic miRNAs and downregulation of miRNAs which promote differentiation and proliferation in age-related degeneration of the organ of Corti may potentially serve as a helpful biomarker for the early detection of age-related hearing loss. This knowledge represents miRNAs as promising diagnostic and therapeutic tools in the near future. © 2017, Springer-Verlag Berlin Heidelberg.

Item Type: Article
Additional Information: cited By 0; Article in Press
Uncontrolled Keywords: Biomarker, Hair cell, Hearing loss, MiRNA, Regeneration
Subjects: WV Otolaryngology
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Jun 2017 09:27
Last Modified: 21 Jun 2017 09:27
URI: http://eprints.skums.ac.ir/id/eprint/190

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