The effect of Melatonin on histological changes of ovary in induced polycystic ovary syndrome model in mice

Ahmadi, M. and Rostamzadeh, A. and Fathi, F. and Mohammadi, M. and Rezaie, M.J. (2017) The effect of Melatonin on histological changes of ovary in induced polycystic ovary syndrome model in mice. Middle East Fertility Society Journal.


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Antioxidants can be used as adjuvant treatment of polycystic ovary syndrome (PCOS). Melatonin (MT) is one of the antioxidant that is used nowadays. Objective: In this study, the effect of MT on the histological changes of ovary in the experimental model of polycystic ovary syndrome is investigated. Methods: In this study 30 immature female NMRI mice were divided into 5 groups including: (1) control group received distilled water, (2) received a dose of 10. mg/kg MT for 5. days, (3) received Dehydroepiandrostenedione (DHEA) at a dose of 6. mg/kg for 20. days to induce PCOS, (4) after induction of PCOS received MT at a dose of 10. mg/kg for 5. days, and (5) received 6. mg/kg DHEA and 10. mg/kg MT for 20. days simultaneously. Results: The evaluation of ovarian tissue characteristics such as the granulosa layer, theca, number and diameter of cysts and follicles was performed. PCOS caused a significant reduction in the number of antral follicles and corpus luteum and an increase in the number of primordial, primary, pre-antral and cystic follicles in comparison with the control group (P. <. 0.05). Moreover, MT resulted in a significant increase in the granulosa layer thickness in group 4 (P. <. 0.001), and group 5 (P = 0.001) and a significant reduction in the thickness of theca layer between groups 4 and 5 compared with group 3 (P. <. 0.001). Conclusion: These findings indicate that MT have a protective effects on polycystic ovary damages induced by DHEA, although the mechanism is unclear. It is likely that this is happening by reducing oxidative damage. © 2017.

Item Type: Article
Additional Information: cited By 0; Article in Press
Uncontrolled Keywords: Antioxidant, Dehydroepiandrostenedione, Melatonin ,Polycystic ovary syndrome
Subjects: WP Gynecology
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Anatomy (Histology and Embryology
Depositing User: zahra bagheri .
Date Deposited: 21 Jun 2017 09:23
Last Modified: 21 Jun 2017 09:23

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