Association analysis of -416 G>C polymorphism of T-cell immunoglobulin and mucin domain-1 gene with asthma in Iran

shirzad, Hedayatollah. and Meshkat, Rezvan. and Ganjalikhani-Hakemi, Mazdak. and Mosayebian, A. and Ghasemi, Ramin. and Deris, Fatemeh. and Parchami Barjui, Shahrbanoo. and Sadri, Maryam. and Salehi, Rasoul. (2015) Association analysis of -416 G>C polymorphism of T-cell immunoglobulin and mucin domain-1 gene with asthma in Iran. International Journal of Immunogenetics, 42 (4). pp. 265-269.


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TIM (T-cell immunoglobulin (Ig) and mucin domain)- 1, one of the members of TIM family, expresses on Th2 cells and promotes the production of Th2 signature cytokines. This can increase a series of responses in these cells which could be one of the causes of asthma or asthma-related phenotypes. The aim of this study was to investigate whether a TIM-1 promoter single nucleotide polymorphism (SNP), �416 G>C, is associated with asthma in Iranian population. In this case–control study, existence of the �416 G>C polymorphism was assessed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) in 300 patients with asthma (97 atopic, 203 nonatopic) and 309 healthy volunteers. Additionally, the relationship between these polymorphism genotypes and total serum IgE levels in this Iranian population was evaluated. We discovered a significant association between the �416 G>C polymorphism and atopic asthma susceptibility in the population, but this SNP showed no connection with nonatopic asthma (P < 0.05). However, our results showed significant relation between this polymorphism and serum IgE level (P < 0.05). Our results suggest that �416 G>C polymorphism in TIM-1 gene could be a predisposing factor for atopic asthma in Iranian population, and CC genotype of this SNP can be associated with increased level of IgE in patients with asthma in the same population.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: immunoglobulin E; kidney injury molecule 1; HAVCR1 protein, human; immunoglobulin E; membrane protein; virus receptor, adult; allergic asthma; Article; asthma; case control study; controlled study; female; genetic association; genetic susceptibility; human; immunoglobulin blood level; Iran; major clinical study; male; polymerase chain reaction; priority journal; restriction fragment length polymorphism; single nucleotide polymorphism; asthma; genetic association study; genetic predisposition; genetics; genotype; middle aged; pathology; promoter region; single nucleotide polymorphism, Adult; Asthma; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Immunoglobulin E; Iran; Male; Membrane Glycoproteins; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, Virus
Subjects: WF Respiratory System
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Health > Department of Epidemiology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 29 Jul 2017 03:40
Last Modified: 07 Apr 2018 06:58

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