The relationship between blood lead level with iron status and hemopoietic parameters in smoker and non-smoker workers at lead battery factory

Sadeghi, Hamidreza. and Ghomashlooyan, Mohsen. and Azami, Mehdi. and Jamshidian Ghalesefidi, Maryam. (2015) The relationship between blood lead level with iron status and hemopoietic parameters in smoker and non-smoker workers at lead battery factory. Comparative Clinical Pathology, 24 (5). pp. 1111-1115.

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Abstract

The present study aimed at evaluating the effect of lead exposure on hemopoietic system (through the index delta-aminolevulinic acid dehydratase [δ-ALAD] activity, hemoglobin concentration [Hb], hematocrit concentration [Hct]) and on iron status (levels of serum iron [Fe], ferritin [Fr], total iron binding capacity [TIBC], percentage of transferrin saturation [TS%]) in Iranian workers at lead batteries factory. Forty-four workers were divided into two groups: smokers (n = 21) and non-smokers (n = 23). Also, 45 healthy subjects were studied as control group. δ-ALAD, iron status, and hematological parameters were evaluated. Activity of δ-ALAD ratio showed significant decrease (p < 0.05), while Hb and Hct were non-significant (p > 0.05) in smoker workers compared to non-smoker and control groups. There was no significant decrease (p > 0.05) in the sera levels of Fe, TS%, and Fr in all workers as compared to control. There was a significant increase in the level of TIBC in workers as compared to control; this elevation is more in smoker than in non-smoker workers. In smoker workers, there was a significant positive correlation between the blood lead levels (BLLs) and Hb, Hct, and TIBC whereas a significant negative correlation was observed between BLLs and Fe and TS%. The results revealed the importance of monitoring the level of iron status in smokers who deal with lead and therefore anemia will develop for them. δ-ALAD ratio was considered to predict the efficiency of heme synthesis as a new marker for the diagnosis of early stage of anemia.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Blood lead levels (BLLs), δ-ALAD, Iron status, Workers, Smoker
Subjects: WH Hemic and Lymphatic System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: Users 1 not found.
Date Deposited: 26 Jul 2017 09:41
Last Modified: 20 May 2018 06:49
URI: http://eprints.skums.ac.ir/id/eprint/1860

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