Multiple sclerosis and air pollution exposure: Mechanisms toward brain autoimmunity

Esmaeil Mousavi, S. and Heydarpour, P. and Reis, J. and Amiri, M. and Sahraian, M.A. (2017) Multiple sclerosis and air pollution exposure: Mechanisms toward brain autoimmunity. Medical Hypotheses, 100. pp. 23-30.

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Abstract

The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major mechanisms involved in MS pathogenesis, such as inflammatory factors expression, free radicals overproduction, the blood brain barrier (BBB) breakdown, neuroinflammation, vitamin D deficiency and mitochondrial dysfunction could also occur due to exposure to air pollutants. A prospective hypothesis is suggested here in which exposure to air pollutants may initiate destructive mechanisms inducing inflammatory-oxidative cascades, reduction of immunological self-tolerance and neurodegeneration leading to brain autoimmunity

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Air pollution, Autoimmunity ,Blood brain barrier, Multiple sclerosis, Neuroinflammation, Oxidative stress
Subjects: WL Nervous system
Divisions: Reserach Vice-Chancellar Department > Social Determinants of Health Research Center
Depositing User: zahra bagheri .
Date Deposited: 21 Jun 2017 07:59
Last Modified: 21 Jun 2017 07:59
URI: http://eprints.skums.ac.ir/id/eprint/182

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